How to Cite this Article: Drago A, Crisafulli C, Serretti A. 2011. The Genetics of Antipsychotic Induced Tremors: A Genome-Wide Pathway Analysis on the STEP-BD SCP Sample. Am J Med Genet Part B 156:975–986.
The genetics of antipsychotic induced tremors: A genome-wide pathway analysis on the STEP-BD SCP sample†
Article first published online: 11 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 156, Issue 8, pages 975–986, December 2011
How to Cite
Drago, A., Crisafulli, C. and Serretti, A. (2011), The genetics of antipsychotic induced tremors: A genome-wide pathway analysis on the STEP-BD SCP sample. Am. J. Med. Genet., 156: 975–986. doi: 10.1002/ajmg.b.31245
- Issue published online: 20 OCT 2011
- Article first published online: 11 OCT 2011
- Manuscript Accepted: 16 SEP 2011
- Manuscript Received: 1 JUN 2011
- NIMH. Grant Number: 2N01MH080001-001
- pathway analysis;
- extrapyramidal symptom;
Extrapyramidal symptoms (EPS) are associated with antipsychotic treatment. The exact definition of the genetic variants that influence the antipsychotic induced EPS would dramatically increase the quality of antipsychotic prescriptions. We investigated this issue in a subsample of the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). Four hundred nine manic patients were treated with antipsychotics and had complete clinical and genetic data. Outcome was an item of the Clinical Monitoring Form which scored tremors from 0 to 4 at each clinical visit. Visits were scheduled according to clinical issues, based on a naturalistic approach. A genomic inflation factor of 1.017 resulted after genetic quality control. Single SNPs GWAS (Plink) and molecular pathway GWAS were conducted (SNP ratio test, KEGG depository). No single SNP reached GWAS significance level of association. Molecular pathways related to cell survival events and lipid synthesis were significantly associated with antipsychotic induced EPS (P = 0.0009 for Hsa04512, Hsa01031, Hsa00230, Hsa04510, Hsa03320, Hsa04930, and Hsa04115; P = 0.0019 for Hsa04020 and Hsa00561). This finding was consistent with previous GWAS studies. © 2011 Wiley Periodicals, Inc.