The present work complies with Spain's current laws.
Article first published online: 7 DEC 2011
Copyright © 2011 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 159B, Issue 1, pages 94–103, January 2012
How to Cite
Carreño, O., Corominas, R., Fernández-Morales, J., Camiña, M., Sobrido, M.-J., Fernández-Fernández, J. M., Pozo-Rosich, P., Cormand, B. and Macaya, A. (2012), SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population. Am. J. Med. Genet., 159B: 94–103. doi: 10.1002/ajmg.b.32007
The authors declare that they have no conflict of interest.
How to cite this article: Carreño O, Corominas R, Fernández-Morales J, Camiña M, Sobrido M-J, Fernández-Fernández JM, Pozo-Rosich P, Cormand B, Macaya A. 2012. SNP Variants Within the Vanilloid TRPV1 and TRPV3 Receptor Genes Are Associated With Migraine in the Spanish Population. Am J Med Genet Part B 159B:94–103.
- Issue published online: 16 DEC 2011
- Article first published online: 7 DEC 2011
- Manuscript Accepted: 14 NOV 2011
- Manuscript Received: 26 MAY 2011
- Ministerio de Ciencia e Innovación (Spain)
- Fondos Europeos de Desarrollo Regional (FEDER)
- Plan E. Grant Numbers: SAF 2009-13182-C01, SAF 2009-13182-C02, SAF 2009-13182-C03
- Fondo de Investigación Sanitaria (Red HERACLES). Grant Number: RD06/0009
- Agència de Gestió d'Ajuts Universitaris i de Recerca. Grant Numbers: 2009SGR078, 2009SGR0971, 2009SGR1369
- Fundació La Marató de TV3, Catalunya, Spain. Grant Number: 072310
- association study;
The transient receptor potential (TRP) superfamily of non-selective cationic channels are involved in several processes plausibly relevant to migraine pathophysiology, including multimodal sensory and pain perception, central and peripheral sensitization, and regulation of calcium homeostasis. With the aim of identifying single nucleotide polymorphisms (SNPs) in TRP genes that may confer increased genetic susceptibility to migraine, we carried out a case–control genetic association study with replication, including a total of 1,040 cases and 1,037 controls. We genotyped 149 SNPs covering 14 TRP genes with known brain expression. The two-stage study comprised samples of 555 and 485 Spanish, Caucasian patients, selected according to the ICHD-II criteria for the diagnosis of migraine without aura (MO) or migraine with aura (MA). In the discovery sample, 19 SNPs in ten TRP genes showed nominal association (P < 0.05) with MO, MA, or overall migraine. In the replication sample, nominal association was confirmed for TRPV3 rs7217270 in MA and TRPV1 rs222741 in the overall migraine group. Risk haplotypes were identified for seven of the genes showing nominal association in the discovery set, but none of them was replicated. The present findings suggest that members of the vanilloid TRPV subfamily of receptors contribute to the genetic susceptibility to migraine in the Spanish population. © 2011 Wiley Periodicals, Inc.