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SNP variants within the vanilloid TRPV1 and TRPV3 receptor genes are associated with migraine in the Spanish population§

Authors

  • Oriel Carreño,

    1. Facultat de Biologia, Departament de Genètica, Universitat de Barcelona, Barcelona, Spain
    2. Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain
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  • Roser Corominas,

    1. Pediatric Neurology Research Group, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Catalonia, Spain
    2. Center for Biomedical Network Research on Rare Diseases (CIBERER), Institute of Health Carlos III, Barcelona, Spain
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  • Jessica Fernández-Morales,

    1. Headache and Neurological Pain Laboratory, Vall d'Hebron Research Institute and Headache Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain
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  • Montserrat Camiña,

    1. Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Galicia, Spain
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  • María-Jesús Sobrido,

    1. Center for Biomedical Network Research on Rare Diseases (CIBERER), Institute of Health Carlos III, Barcelona, Spain
    2. Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Galicia, Spain
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  • José Manuel Fernández-Fernández,

    1. Laboratory of Molecular Physiology and Channelopathies, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain
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  • Patricia Pozo-Rosich,

    1. Headache and Neurological Pain Laboratory, Vall d'Hebron Research Institute and Headache Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain
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  • Bru Cormand,

    1. Facultat de Biologia, Departament de Genètica, Universitat de Barcelona, Barcelona, Spain
    2. Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Spain
    3. Center for Biomedical Network Research on Rare Diseases (CIBERER), Institute of Health Carlos III, Barcelona, Spain
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  • Alfons Macaya

    Corresponding author
    1. Pediatric Neurology Research Group, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Catalonia, Spain
    • Pediatric Neurology Research Group, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Catalonia, Spain.
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  • The present work complies with Spain's current laws.

  • The authors declare that they have no conflict of interest.

  • §

    How to cite this article: Carreño O, Corominas R, Fernández-Morales J, Camiña M, Sobrido M-J, Fernández-Fernández JM, Pozo-Rosich P, Cormand B, Macaya A. 2012. SNP Variants Within the Vanilloid TRPV1 and TRPV3 Receptor Genes Are Associated With Migraine in the Spanish Population. Am J Med Genet Part B 159B:94–103.

Abstract

The transient receptor potential (TRP) superfamily of non-selective cationic channels are involved in several processes plausibly relevant to migraine pathophysiology, including multimodal sensory and pain perception, central and peripheral sensitization, and regulation of calcium homeostasis. With the aim of identifying single nucleotide polymorphisms (SNPs) in TRP genes that may confer increased genetic susceptibility to migraine, we carried out a case–control genetic association study with replication, including a total of 1,040 cases and 1,037 controls. We genotyped 149 SNPs covering 14 TRP genes with known brain expression. The two-stage study comprised samples of 555 and 485 Spanish, Caucasian patients, selected according to the ICHD-II criteria for the diagnosis of migraine without aura (MO) or migraine with aura (MA). In the discovery sample, 19 SNPs in ten TRP genes showed nominal association (P < 0.05) with MO, MA, or overall migraine. In the replication sample, nominal association was confirmed for TRPV3 rs7217270 in MA and TRPV1 rs222741 in the overall migraine group. Risk haplotypes were identified for seven of the genes showing nominal association in the discovery set, but none of them was replicated. The present findings suggest that members of the vanilloid TRPV subfamily of receptors contribute to the genetic susceptibility to migraine in the Spanish population. © 2011 Wiley Periodicals, Inc.

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