How to Cite this Article: Judy JT, Seifuddin F, Mahon PB, Huo Y, Goes FS, Jancic D, Schweizer B, Mondimore FM, MacKinnon DF, DePaulo JR, Gershon ES, McMahon FJ, Cutler DJ, Zandi PP, Potash JB, Willour VL. 2012. Association Study of Serotonin Pathway Genes in Attempted Suicide. Am J Med Genet Part B 159B:112–119.
Association study of serotonin pathway genes in attempted suicide†
Version of Record online: 13 DEC 2011
Copyright © 2011 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 159B, Issue 1, pages 112–119, January 2012
How to Cite
Judy, J. T., Seifuddin, F., Mahon, P. B., Huo, Y., Goes, F. S., Jancic, D., Schweizer, B., Mondimore, F. M., MacKinnon, D. F., DePaulo, J. R., Gershon, E. S., McMahon, F. J., Cutler, D. J., Zandi, P. P., Potash, J. B. and Willour, V. L. (2012), Association study of serotonin pathway genes in attempted suicide. Am. J. Med. Genet., 159B: 112–119. doi: 10.1002/ajmg.b.32008
- Issue online: 16 DEC 2011
- Version of Record online: 13 DEC 2011
- Manuscript Accepted: 16 NOV 2011
- Manuscript Received: 25 APR 2011
- National Institute of Mental Health. Grant Number: MH079240
- American Foundation for Suicide Prevention
- suicidal behavior;
- bipolar disorder;
- major depression
Epidemiological studies, such as family, twin, and adoption studies, demonstrate the presence of a heritable component to both attempted and completed suicide. Some of this heritability is accounted for by the presence of comorbid psychiatric disorders, but the evidence also indicates that a portion of this heritability is specific to suicidality. The serotonergic system has been studied extensively in this phenotype, but findings have been inconsistent, possibly due to the presence of multiple susceptibility variants and/or gene–gene interactions. In this study, we genotyped 174 tag and coding single nucleotide polymorphisms (SNPs) from 17 genes within the serotonin pathway on 516 subjects with a major mood disorder and a history of a suicide attempt (cases) and 515 healthy controls, with the goal of capturing the common genetic variation across each of these candidate genes. We tested the 174 markers in single-SNP, haplotype, gene-based, and epistasis analyses. While these association analyses identified multiple marginally significant SNPs, haplotypes, genes, and interactions, none of them survived correction for multiple testing. Additional studies, including assessment in larger sample sets and deep resequencing to identify rare causal variants, may be required to fully understand the role that the serotonin pathway plays in suicidal behavior. © 2011 Wiley Periodicals, Inc.