Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population

Authors

  • Yuhui Sun,

    1. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine & Peking Union Medical College, Tsinghua University, Beijing, China
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  • Jiexu Zhang,

    1. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine & Peking Union Medical College, Tsinghua University, Beijing, China
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  • Yanbo Yuan,

    1. Institute of Mental Health, Peking University, Beijing, China
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  • Xin Yu,

    1. Institute of Mental Health, Peking University, Beijing, China
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  • Yan Shen,

    1. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine & Peking Union Medical College, Tsinghua University, Beijing, China
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  • Qi Xu

    Corresponding author
    1. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine & Peking Union Medical College, Tsinghua University, Beijing, China
    • National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine & Peking Union Medical College, Tsinghua University, No.5 Dongdan San Tiao, Beijing 100005, China.
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  • How to Cite this Article: Sun Y, Zhang J, Yuan Y, Yu X, Shen Y, Xu Q. 2012. Study of a Possible Role of the Monoamine Oxidase A (MAOA) Gene in Paranoid Schizophrenia Among a Chinese Population. Am J Med Genet Part B 159B:104–111.

  • Yuhui Sun and Jiexu Zhang are contributed equally to this study.

Abstract

Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered as being two of the most important neurotransmitters involved in the pathophysiology of schizophrenia. To study a possible role of the MAOA gene in conferring susceptibility to schizophrenia, the present study genotyped the variable number of tandem repeat (VNTR) polymorphism and 41 SNPs across this gene among 555 unrelated patients with paranoid schizophrenia and 567 unrelated healthy controls. Quantitative real-time PCR analysis was employed to quantify expression of MAOA mRNA in 73 drug-free patients. While none of these genotyped DNA markers showed allelic association with paranoid schizophrenia, haplotypic association was found for the VNTR-rs6323, VNTR-rs1137070, and VNTR-rs6323-rs1137070 haplotypes in female subjects. Nevertheless, no significant change of the expression of MAOA mRNA was detected in either female or male patients with paranoid schizophrenia. Our study suggests that the interaction between genetic variants within the MAOA gene may contribute to an increased risk of paranoid schizophrenia, but the precise mechanism needs further investigation. © 2011 Wiley Periodicals, Inc.

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