How to Cite this Article: Sun Y, Zhang J, Yuan Y, Yu X, Shen Y, Xu Q. 2012. Study of a Possible Role of the Monoamine Oxidase A (MAOA) Gene in Paranoid Schizophrenia Among a Chinese Population. Am J Med Genet Part B 159B:104–111.
Article first published online: 7 DEC 2011
Copyright © 2011 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 159B, Issue 1, pages 104–111, January 2012
How to Cite
Sun, Y., Zhang, J., Yuan, Y., Yu, X., Shen, Y. and Xu, Q. (2012), Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population. Am. J. Med. Genet., 159B: 104–111. doi: 10.1002/ajmg.b.32009
Yuhui Sun and Jiexu Zhang are contributed equally to this study.
- Issue published online: 16 DEC 2011
- Article first published online: 7 DEC 2011
- Manuscript Accepted: 14 NOV 2011
- Manuscript Received: 7 FEB 2011
- National Basic Research Program of China. Grant Numbers: 2010CB529603, 2012CB517902
- National Natural Science Foundation of China. Grant Numbers: 30971001, 31021091
- Beijing Natural Science Foundation. Grant Number: 7102109
- Fok Ying Tong Education Foundation. Grant Number: 121024
- MAOA gene;
- paranoid schizophrenia;
- mRNA expression
Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered as being two of the most important neurotransmitters involved in the pathophysiology of schizophrenia. To study a possible role of the MAOA gene in conferring susceptibility to schizophrenia, the present study genotyped the variable number of tandem repeat (VNTR) polymorphism and 41 SNPs across this gene among 555 unrelated patients with paranoid schizophrenia and 567 unrelated healthy controls. Quantitative real-time PCR analysis was employed to quantify expression of MAOA mRNA in 73 drug-free patients. While none of these genotyped DNA markers showed allelic association with paranoid schizophrenia, haplotypic association was found for the VNTR-rs6323, VNTR-rs1137070, and VNTR-rs6323-rs1137070 haplotypes in female subjects. Nevertheless, no significant change of the expression of MAOA mRNA was detected in either female or male patients with paranoid schizophrenia. Our study suggests that the interaction between genetic variants within the MAOA gene may contribute to an increased risk of paranoid schizophrenia, but the precise mechanism needs further investigation. © 2011 Wiley Periodicals, Inc.