How to Cite this Article: Li WJ, Kou CG, Yu Y, Sun S, Zhang X, Kosten TR, Zhang XY. 2012. Association of Catechol-O-Methyltransferase Gene Polymorphisms With Schizophrenia and Negative Symptoms in a Chinese Population. Am J Med Genet Part B 159B:370–375.
Article first published online: 21 FEB 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 159B, Issue 4, pages 370–375, June 2012
How to Cite
Li, W. J., Kou, C. G., Yu, Y., Sun, S., Zhang, X., Kosten, T. R. and Zhang, X. Y. (2012), Association of Catechol-O-methyltransferase gene polymorphisms with schizophrenia and negative symptoms in a Chinese population. Am. J. Med. Genet., 159B: 370–375. doi: 10.1002/ajmg.b.32038
Wen Jun Li and Chang Gui Kou contributed equally to this work.
- Issue published online: 7 MAY 2012
- Article first published online: 21 FEB 2012
- Manuscript Accepted: 31 JAN 2012
- Manuscript Received: 12 OCT 2011
- Stanley Medical Research Institute. Grant Numbers: 03T-459, 05T-726
- Department of Veterans Affairs, VISN 16
- Mental Illness Research, Education and Clinical Center (MIRECC)
- United States National Institute of Health. Grant Numbers: K05-DA0454, P50-DA18827, U01-MH79639
- negative symptom
The gene encoding Catechol-O-methyltransferase (COMT), a dopamine catabolic enzyme, has been associated inconsistently with schizophrenia in spite of consistent evidence for dopaminergic dysfunction in the prefrontal cortex (PFC) of schizophrenia. Since one contribution to this inconsistency might be genetic heterogeneity, this study investigated whether the COMT gene was associated with the development and symptoms of schizophrenia in relatively genetically homogeneous Chinese schizophrenic patients. We analyzed two polymorphisms (rs740603 and rs4818) of the COMT gene in a case-control study of 604 Han Chinese (284 patients and 320 controls). The patients' psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS). We found no significant differences in the rs740603 and rs4818 genotype and allele distributions between the patient and control groups. Quantitative trait analysis by the UNPHASED program showed that the rs740603 and rs740603(G)-rs4818(G) haplotypes were associated with negative symptoms in the schizophrenic patients, particularly among female patients. Thus, the COMT gene polymorphisms may not contribute to the susceptibility to schizophrenia, but may contribute to the negative symptoms of schizophrenia among Han Chinese. © 2012 Wiley Periodicals, Inc.