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ZNF804A and schizophrenia susceptibility in Asian populations§

Authors

  • Ming Li,

    1. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    2. Graduate School of Chinese Academy of Sciences, Beijing, China
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  • Cui-Juan Shi,

    1. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Science and Peking Union Medical College, Tsinghua University, Beijing, China
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  • Yong-Yong Shi,

    1. Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    2. Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China
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  • Xiong-Jian Luo,

    1. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
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  • Xue-Bin Zheng,

    1. Human Genetics, Genome Institute of Singapore, A*STAR, Singapore
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  • Zhi-Qiang Li,

    1. Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    2. Shanghai Genome Pilot Institutes for Genomics and Human Health, Shanghai, China
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  • Jian-Jun Liu,

    1. Human Genetics, Genome Institute of Singapore, A*STAR, Singapore
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  • Siow-Ann Chong,

    1. Institute of Mental Health, Singapore
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  • Jimmy Lee,

    1. Institute of Mental Health, Singapore
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  • Yi Wang,

    1. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    2. Graduate School of Chinese Academy of Sciences, Beijing, China
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  • Xing-Yan Liu,

    1. The Second People's Hospital of Yuxi City, Yuxi, China
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  • Li-De Yin,

    1. The Second People's Hospital of Yuxi City, Yuxi, China
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  • Xing-Fu Pu,

    1. The Second People's Hospital of Yuxi City, Yuxi, China
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  • Hong-Bo Diao,

    1. Yunnan Mental Health Hospital, Kunming, China
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  • Qi Xu Ph.D.,

    Corresponding author
    1. National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Science and Peking Union Medical College, Tsinghua University, Beijing, China
    • National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Science and Peking Union Medical College, Tsinghua University, Dong Dan San Tiao No. 5, Beijing 100005, China
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  • Bing Su Ph.D.

    Corresponding author
    1. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
    • State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 East Jiao-chang Rd., Kunming, Yunnan 650223, China
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  • The authors declare no conflict of interest.

  • How to Cite this Article: Li M, Shi C-J, Shi Y-Y, Luo X-J, Zheng X-B, Li Z-Q, Liu J-J, Chong S-A, Lee J, Wang Y, Liu X-Y, Yin L-D, Pu X-F, Diao H-B, Xu Q, Su B. 2012. ZNF804A and Schizophrenia Susceptibility in Asian Populations. Am J Med Genet Part B.

  • §

    Ming Li, Cui-Juan Shi, and Yong-Yong Shi contributed equally to this work.

Abstract

ZNF804A, a recently identified risk gene for schizophrenia, has been extensively investigated and the principle finding for this locus has been the association with SNP rs1344706 in populations of European ancestries. However, in Asian populations, only a few studies have been conducted for rs1344706 and the results were inconsistent. Here, we studied rs1344706 and schizophrenia susceptibility in multiple Asian case–control samples (10 Chinese and 2 Japanese samples; N = 21,062), and the meta-analyses indicated non-significant association of rs1344706 with schizophrenia (P = 0.26), suggesting the same SNP identified in European samples is not predisposing risk in Asians. Further genotyping and association analyses of a set of SNPs spanning the entire genomic region of ZNF804A (520 kb) identified no association except for SNP rs359895 (P = 7.8 × 10−5, N = 5,172), a newly reported risk SNP located in the ZNF804A promoter region with functional implications. This suggests that ZNF804A may also contribute to schizophrenia susceptibility in Asians although the risk SNP is different from that in Europeans, and it was supported by the detected up-regulation of ZNF804A mRNA expression in the blood cells of Chinese schizophrenia patients compared with normal controls (P = 0.004). Additionally, the linkage disequilibrium (LD) structure analyses using data from HapMap indicated distinct LD blocks across ZNF804A between Chinese and Europeans, which may explain the different association patterns between them, and also highlight the compounding difficulty of genetic studies of complex diseases like schizophrenia when studying multiple ethnic populations. © 2012 Wiley Periodicals, Inc.

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