The authors have no conflict of interest to declare.
Article first published online: 13 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 159B, Issue 8, pages 908–927, December 2012
How to Cite
Quilter, C.R., Sargent, C.A., Bauer, J., Bagga, M. R., Reiter, C. P., Hutchinson, E. L., Southwood, O. I., Evans, G., Mileham, A., Griffin, D.K. and Affara, N.A. (2012), An association and haplotype analysis of porcine maternal infanticide: A model for human puerperal psychosis?. Am. J. Med. Genet., 159B: 908–927. doi: 10.1002/ajmg.b.32097
How to Cite this Article: Quilter CR, Sargent CA, Bauer J, Bagga M, Reiter C, Hutchinson E, Southwood O, Evans G, Mileham A, Griffin DK, Affara NA. 2012. An Association and Haplotype Analysis of Porcine Maternal Infanticide: A Model for Human Puerperal Psychosis? Am J Med Genet Part B 159B:908–927.
- Issue published online: 8 NOV 2012
- Article first published online: 13 SEP 2012
- Manuscript Accepted: 9 AUG 2012
- Manuscript Received: 13 MAR 2012
- Department for Environment, Food and Rural Affairs (DEFRA)
- animal model;
- postnatal mood
An association analysis using the Illumina porcine SNP60 beadchip was performed to identify SNPs significantly associated with porcine maternal infanticide. We previously hypothesised that this was a good animal model for human puerperal psychosis, an extreme form of postnatal mood disorder. Animals were selected from carefully phenotyped unrelated infanticide and control groups (representing extremes of the phenotypic spectrum), from four different lines. Permutation and sliding window analyses and an analysis to see which haplotypes were in linkage disequilibrium (LD) were compared to identify concordant regions. Across all analyses, intervals on SSCs 1, 3, 4, 10, and 13 were constant, contained genes associated with psychiatric or neurological disorders and were significant in multiple lines. The strongest (near GWS) consistent candidate region across all analyses and all breeds was the one located on SSC3 with one peak at 23.4 Mb, syntenic to a candidate region for bipolar disorder and another at 31.9 Mb, syntenic to a candidate region for human puerperal psychosis (16p13). From the haplotype/LD analysis, two regions reached genome wide significance (GWS): the first on SSC4 (KHDRBS3 to FAM135B), which was significant (−logP 5.57) in one Duroc based breed and is syntenic to a region in humans associated with cognition and neurotism; the second on SSC15, which was significant (−log10P 5.68) in two breeds and contained PAX3, which is expressed in the brain. © 2012 Wiley Periodicals, Inc.