Association of KIBRA with episodic and working memory: A meta-analysis

Authors

  • Annette Milnik,

    Corresponding author
    1. Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland
    2. Department of Neurology, University of Magdeburg, Magdeburg, Germany
    • Division of Molecular Neuroscience, University of Basel, Birmannsgasse 8, 4055 Basel, Switzerland.
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  • Angela Heck,

    1. Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland
    2. Life Sciences Training Facility, Department Biozentrum, University of Basel, Basel, Switzerland
    3. University Psychiatric Clinics, University of Basel, Basel, Switzerland
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  • Christian Vogler,

    1. Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland
    2. Life Sciences Training Facility, Department Biozentrum, University of Basel, Basel, Switzerland
    3. University Psychiatric Clinics, University of Basel, Basel, Switzerland
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  • Hans-Jochen Heinze,

    1. Department of Neurology, University of Magdeburg, Magdeburg, Germany
    2. Leibniz Institute for Neurobiology, Magdeburg, Germany
    3. Helmholtz Center for Neurodegenerative Diseases, Magdeburg, Germany
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  • Dominique J.-F. de Quervain,

    1. University Psychiatric Clinics, University of Basel, Basel, Switzerland
    2. Division of Cognitive Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland
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  • Andreas Papassotiropoulos

    1. Division of Molecular Neuroscience, Department of Psychology, University of Basel, Basel, Switzerland
    2. Life Sciences Training Facility, Department Biozentrum, University of Basel, Basel, Switzerland
    3. University Psychiatric Clinics, University of Basel, Basel, Switzerland
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  • The authors declare no conflict of interest.

  • How to Cite this Article: Milnik A, Heck A, Vogler C, Heinze H-J, de Quervain, DJ-F, Papassotiropoulos A. 2012. Association of KIBRA With Episodic and Working Memory: A Meta-Analysis. Am J Med Genet Part B 159B:958–969.

Abstract

WWC1 was first implicated in human cognition through a genome wide association study in 2006 that reported an association of the intronic single nucleotide polymorphism (SNP) rs17070145 with episodic memory performance. WWC1 encodes the protein KIBRA, which is almost ubiquitously expressed. Together with its binding partners, KIBRA is assumed to play a role in synaptic plasticity. T-allele carriers of SNP rs17070145 have been reported to outperform individuals that are homozygous for the C-allele in episodic memory tasks. Here we report two random effects meta-analyses testing the association of rs17070145 with episodic and working memory. All currently available population-based association studies that investigated effects of rs17070145 on episodic or working memory were included in the analyses. Where performance measures for multiple domain-specific tasks were available for a given study population, averaged effect size estimates were calculated. The performed meta-analyses relied on 17 samples that were tested for episodic memory performance (N = 8,909) and 9 samples that had performed working memory tasks (N = 4,696). We report a significant association of rs17070145 with both episodic (r = 0.068, P = 0.001) and working memory (r = 0.035, P = 0.018). In summary, our findings indicate that SNP rs17070145 located within KIBRA explains 0.5% of the variance for episodic memory tasks and 0.1% of the variance for working memory tasks in samples of primarily Caucasian background. © 2012 Wiley Periodicals, Inc.

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