How to Cite this Article: Zou L, Chen W, Shao S, Sun Z, Zhong R, Shi J, Miao X, Song R. 2012. Genetic Variant in KIAA0319, But Not in DYX1C1, Is Associated With Risk of Dyslexia: An Integrated Meta-Analysis. Am J Med Genet Part B 159B:970–976.
Article first published online: 12 OCT 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 159B, Issue 8, pages 970–976, December 2012
How to Cite
Zou, L., Chen, W., Shao, S., Sun, Z., Zhong, R., Shi, J., Miao, X. and Song, R. (2012), Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: An integrated meta-analysis. Am. J. Med. Genet., 159B: 970–976. doi: 10.1002/ajmg.b.32102
The authors have declared no conflicts of interest.
- Issue published online: 8 NOV 2012
- Article first published online: 12 OCT 2012
- Manuscript Accepted: 14 SEP 2012
- Manuscript Received: 15 JUN 2012
- National Natural Science Foundation of China. Grant Number: NSFC-30600501 and NSFC-81273092
- Fundamental Research Funds for the Central Universities. Grant Number: HUST-2010MS124
DYX1C1 and KIAA0319 have been two of the most extensively studied candidate genes for dyslexia given their important roles in the neuronal migration and neurite growth. The −3G > A in DYX1C1 and the 931C > T in KIAA0319 were of special interest for dyslexia but with inconsistent results. We performed a meta-analysis integrating case–control and transmission/disequilibrium test (TDT) studies to clearly discern the effect of these two variants in dyslexia. Data from case–control and TDT studies were analyzed in an allelic model using the Catmap software. In overall meta-analysis, the pooled OR for the −3A allele and the 931T allele was 0.68 (95% CI = 0.25–1.87, Pheterogeneity = 0.000) and 0.87 (95% CI = 0.78–0.98, Pheterogeneity = 0.125), respectively. The stratified analysis showed that the between-study heterogeneity regarding the −3G > A polymorphism might be accounted by the publication year. Additionally, the sensitivity analysis of −3G > A polymorphism indicated the stability of the result. In conclusion, our results suggested that the 931C > T variant in KIAA0319, but not the −3G > A in DYX1C1, was significantly associated with the risk of dyslexia. © 2012 Wiley Periodicals, Inc.