How to Cite this Article: Lei J, Xu H, Liang H, Su L, Zhang J, Huang X, Song Z, Le W, Deng H, 2012. Gene Expression Changes in Peripheral Blood From Chinese Han Patients With Tourette Syndrome. Am J Med Genet Part B 159B:977–980.
Article first published online: 17 OCT 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 159B, Issue 8, pages 977–980, December 2012
How to Cite
Lei, J., Xu, H., Liang, H., Su, L., Zhang, J., Huang, X., Song, Z., Le, W. and Deng, H. (2012), Gene expression changes in peripheral blood from chinese han patients with tourette syndrome. Am. J. Med. Genet., 159B: 977–980. doi: 10.1002/ajmg.b.32103
Jing Lei, Hongbo Xu, and Hui Liang contributed equally to this work.
- Issue published online: 8 NOV 2012
- Article first published online: 17 OCT 2012
- Manuscript Accepted: 21 SEP 2012
- Manuscript Received: 19 JAN 2012
- National Natural Science Foundation of China. Grant Number: 30871351
- Fund of Hunan Province for Distinguished Young Scholar, Republic of China. Grant Number: 09JJ1005
- Sheng Hua Scholars Program of Central South University, China
- Program for New Century Excellent Talents in University of Ministry of Education of P.R. China. Grant Number: NCET-080563
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry and the Construction Fund for Key Subjects of the Third Xiangya Hospital, Central South University
- Tourette syndrome;
- gene expression;
- quantitative real-time PCR;
- the amyloid precursor protein-binding protein A2 gene
To evaluate whether gene expression in chromosome 15q13–q22.3 region is responsible for the development of Tourette syndrome (TS). Eighty-four unrelated Chinese Han patients with TS (male/female = 68/16; mean age 9.92 ± 3.98 years) and 100 sex, age, and ethnicity matched normal controls (male/female = 80/20; mean age 10.90 ± 5.86 years) were enrolled in this study. We performed quantitative real-time PCR on a subset of seven genes: the L-histidine decarboxylase gene (HDC), the HECT domain and RCC-1 like domain 1 gene (HERC1), the HECT domain and RCC-1 like domain 2 gene (HERC2), the cholinergic receptor, neuronal nicotinic alpha polypeptide 7 gene (CHRNA7), the ubiquitin protein ligase E3A gene (UBE3A), the ubiquitin specific peptidase 3 gene (USP3) and the amyloid precursor protein-binding protein A2 gene (APBA2) previously reported to be stably expressed in brain tissue. A significant difference was shown for the APBA2 gene expression of peripheral lymphocytes between Chinese Han TS group and healthy controls (relative expression: 0.21 ± 0.16-fold decrease in patients versus normal, P < 0.01). Indicating that the APBA2 gene is a promising peripheral blood biomarker that discriminates between patients with TS and healthy subjects. Further studies into this gene and its protein products may provide insights into the pathogenesis of TS. © 2012 Wiley Periodicals, Inc.