How to Cite this Article: Chen J, Xu Y, Zhang K, Liu Z, Xu C, Shen Y, Xu Q. 2012. Comparative Study of Regional Homogeneity in Schizophrenia and Major Depressive Disorder. Am J Med Genet Part B 162B:36–43.
Article first published online: 20 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 162, Issue 1, pages 36–43, January 2013
How to Cite
Chen, J., Xu, Y., Zhang, K., Liu, Z., Xu, C., Shen, Y. and Xu, Q. (2013), Comparative study of regional homogeneity in schizophrenia and major depressive disorder. Am. J. Med. Genet., 162: 36–43. doi: 10.1002/ajmg.b.32116
Conflict of interest: All the authors listed have read through the manuscript, approved for publication and declared no conflict of interest. Jun Chen had full access to all of the data in the study and took his responsibility for the integrity of the data and the accuracy of data analysis.
- Issue published online: 18 DEC 2012
- Article first published online: 20 NOV 2012
- Manuscript Accepted: 23 OCT 2012
- Manuscript Received: 9 AUG 2012
- National Basic Research Program of China. Grant Numbers: 2010CB529603, 2012CB517902
- National Natural Science Foundation of China. Grant Numbers: 30971001, 30971054, 31021091, 81171290
- Beijing Natural Science Foundation. Grant Number: 7102109
- Fok Ying Tong Education Foundation. Grant Number: 121024
- major depressive disorder;
- resting-state functional magnetic resonance imaging;
- regional homogeneity;
- comparative study
Compelling evidence suggests that there is a considerable overlap in structural and functional alternation in the brain between different neuropsychiatric disorders. However, whether these overlaps are specific for schizophrenia has yet to be investigated. A total of 36 patients with paranoid schizophrenia, 43 patients with major depressive disorder (MDD), and 44 healthy controls were recruited to undergo resting-state functional magnetic resonance imaging (rs-fMRI) for analysis of regional homogeneity (ReHo). Twelve regions of interest (ROIs) in the frontal and temporal lobes were generated and one-way ANOVA was performed to test the ReHo differences within these ROIs between the above three groups. The ReHo values within ROIs were extracted to investigate whether a left-right asymmetry existed in a mental disorder. One-way ANOVA showed significant differences in ReHo in the right superior frontal gyrus and left superior temporal gyrus; post hoc analysis revealed that schizophrenic patients had lower ReHo in the left superior temporal gyrus than either control subjects or patients with MDD. Increased ReHo was observed in the right superior frontal gyrus in schizophrenic patients compared with control subjects, and a left-less-than-right asymmetry was also found in this region in schizophrenic patients. The above alterations in ReHo were not affected by age and genders. Our study suggests that the altered ReHo in the superior frontal and temporal gyrus may be specific for schizophrenia rather than MDD. A left-less-than-right asymmetry activation pattern may exist in the resting-state superior frontal gyrus in schizophrenia. This finding would be helpful for better understanding the pathological mechanisms of schizophrenia. © 2012 Wiley Periodicals, Inc.