Phenotype refinement for comorbid attention deficit hyperactivity disorder and reading disability

Authors

  • Abdullah R. Sheikhi,

    1. School of Psychology & Speech Pathology, Curtin Health Innovation Research Institute, Curtin University, Western Australia, Australia
    2. Department of Biological Sciences, Benghazi University, Benghazi, Libya
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  • Neilson Martin,

    1. School of Psychology & Speech Pathology, Curtin Health Innovation Research Institute, Curtin University, Western Australia, Australia
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  • David Hay,

    1. School of Psychology & Speech Pathology, Curtin Health Innovation Research Institute, Curtin University, Western Australia, Australia
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  • Jan P. Piek

    Corresponding author
    1. School of Psychology & Speech Pathology, Curtin Health Innovation Research Institute, Curtin University, Western Australia, Australia
    • School of Psychology & Speech Pathology, Curtin University, GPO Box U1987, Perth, Western Australia 6845, Australia.
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  • How to Cite this Article: Sheikhi AR, Martin N, Hay D, Piek JP. 2012. Phenotype Refinement for Comorbid Attention Deficit Hyperactivity Disorder and Reading Disability. Am J Med Genet Part B 162B:44–54.

Abstract

Comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and reading disability (RD) is common; however, the heritability of this comorbidity is not well understood. This may be due to the complexity and heterogeneity of ADHD and RD phenotypes. Using alternative ADHD–RD sub-phenotypes instead of those arising from the DSM-IV may lead to greater success in the search for comorbid ADHD–RD susceptibility genes. Therefore, this study aims to refine ADHD–RD phenotypes into homogenous informative sub-phenotypes using latent class analysis (LCA). LCA was performed on 2,610 Australian twin families (6,535 individuals) in order to generate probabilistic genetically distinct classes that define ADHD–RD subtypes, including comorbidity, based on related symptom clusters. The LCA separated the phenotypes for ADHD and RD into nine classes. One class was unaffected; three classes demonstrated the three DSM-IV subtypes of ADHD, three subtypes showed different severities of RD, and two classes expressed a combination of RD and ADHD subtypes. LCA proved effective in refining the phenotypes of ADHD alone, RD alone, and ADHD–RD comorbidity, and its ability to classify them into homogenous groups based on clusters of symptoms, suggesting that the latent classes may be robust enough to use in molecular genetic studies. © 2012 Wiley Periodicals, Inc.

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