How to Cite this Article: Tran C, Gagnon F, Wigg KG, Feng Y, Gomez L, Cate-Carter TD, Kerr EN, Field LL, Kaplan BJ, Lovett MW, Barr CL. 2013. A Family-Based Association Analysis and Meta-Analysis of the Reading Disabilities Candidate Gene DYX1C1. Am J Med Genet Part B 162B:146–156..
A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1†
Article first published online: 22 JAN 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 162, Issue 2, pages 146–156, March 2013
How to Cite
Tran, C., Gagnon, F., Wigg, K.G., Feng, Y., Gomez, L., Cate-Carter, T.D., Kerr, E.N., Field, L.L., Kaplan, B.J., Lovett, M.W. and Barr, C.L. (2013), A family-based association analysis and meta-analysis of the reading disabilities candidate gene DYX1C1. Am. J. Med. Genet., 162: 146–156. doi: 10.1002/ajmg.b.32123
- Issue published online: 21 FEB 2013
- Article first published online: 22 JAN 2013
- Manuscript Accepted: 7 NOV 2012
- Manuscript Received: 28 JUN 2012
- Canadian Institutes of Health Research. Grant Number: MOP-89855
- chromosome 15q;
Reading disabilities (RD) have a significant genetic basis and have shown linkage to multiple regions including chromosome 15q. Dyslexia susceptibility 1 candidate gene 1 (DYX1C1) on chromosome 15q21 was originally proposed as a candidate gene with two potentially functional polymorphisms at the −3G/A and 1249G/T positions showing association with RD. However, subsequent studies have yielded mixed results. We performed a literature review and meta-analysis of the −3G/A and 1249G/T polymorphisms, including new unpublished data from two family-based samples. Ten markers in DYX1C1 were genotyped in the two independently ascertained samples. Single marker and −3G/A:1249G/T haplotype analyses were performed for RD in both samples, and quantitative trait analyses using standardized reading-related measures was performed in one of the samples. For the meta-analysis, we used a random-effects model to summarize studies that tested for association between −3G/A or 1249G/T and RD. No significant association was found between the DYX1C1 SNPs and RD or any of the reading-related measures tested after correction for the number of tests performed. The previously reported risk haplotype (−3A:1249T) was not biased in transmission. A total of 9 and 10 study samples were included in the meta-analysis of the −3G/A and 1249G/T polymorphisms, respectively. Neither polymorphism reached statistical significance, but the heterogeneity for the 1249G/T polymorphism was high. The results of this study do not provide evidence for association between the putatively functional SNPs −3G/A and 1249G/T and RD. © 2013 Wiley Periodicals, Inc.