How to cite this article: Ayub M, Irfan M, Maclean A, Naeem F, Blackwood D. 2012. Homozygosity Mapping of Depressive Disorder in a Large Family From Pakistan: Significant Linkage on Chromosome 6 and 9. Am J Med Genet Part B 162B:157–162.
Article first published online: 31 DEC 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 162, Issue 2, pages 157–162, March 2013
How to Cite
Ayub, M., Irfan, M., Maclean, A., Naeem, F. and Blackwood, D. (2013), Homozygosity mapping of depressive disorder in a large family from Pakistan: Significant linkage on chromosome 6 and 9. Am. J. Med. Genet., 162: 157–162. doi: 10.1002/ajmg.b.32126
Conflict of interest: none.
- Issue published online: 21 FEB 2013
- Article first published online: 31 DEC 2012
- Manuscript Accepted: 7 DEC 2012
- Manuscript Received: 21 MAY 2012
- Chief Scientist Office of the Scottish Executive
- major depressive disorder;
- homozygosity mapping;
- genetic linkage
A large family with a high prevalence of recurrent major depression and high average inbreeding coefficient was ascertained from rural Pakistan. Subjects were interviewed and diagnosed by a trained psychiatrist, 370 microsatellite markers were genotyped and the program FEstim was used for homozygosity mapping. Significant linkage was found on Chromosome 9 and Chromosome 6 after fine mapping. These regions on Chromosome 6 and 9 may harbor genes which predispose to depression. © 2012 Wiley Periodicals, Inc.