Homozygosity mapping of depressive disorder in a large family from Pakistan: Significant linkage on chromosome 6 and 9


  • How to cite this article: Ayub M, Irfan M, Maclean A, Naeem F, Blackwood D. 2012. Homozygosity Mapping of Depressive Disorder in a Large Family From Pakistan: Significant Linkage on Chromosome 6 and 9. Am J Med Genet Part B 162B:157–162.

  • Conflict of interest: none.


A large family with a high prevalence of recurrent major depression and high average inbreeding coefficient was ascertained from rural Pakistan. Subjects were interviewed and diagnosed by a trained psychiatrist, 370 microsatellite markers were genotyped and the program FEstim was used for homozygosity mapping. Significant linkage was found on Chromosome 9 and Chromosome 6 after fine mapping. These regions on Chromosome 6 and 9 may harbor genes which predispose to depression. © 2012 Wiley Periodicals, Inc.