Conflict of interest: None.
Article first published online: 17 JAN 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 162, Issue 2, pages 169–176, March 2013
How to Cite
Cao, J., LaRocque, E. and Li, D. (2013), Associations of the 5-hydroxytryptamine (serotonin) Receptor 1B gene (HTR1B) with alcohol, cocaine, and heroin abuse. Am. J. Med. Genet., 162: 169–176. doi: 10.1002/ajmg.b.32128
How to Cite this Article: Cao J, LaRocque E, Li D. 2013. Associations of the 5-Hydroxytryptamine (Serotonin) Receptor 1B Gene (HTR1B) With Alcohol, Cocaine, and Heroin Abuse. Am J Med Genet Part B 162B:169–176.
- Issue published online: 21 FEB 2013
- Article first published online: 17 JAN 2013
- Manuscript Accepted: 21 DEC 2012
- Manuscript Received: 7 NOV 2012
- University of Vermont
- National Institutes of Health, USA. Grant Numbers: DA12849, DA12690, AA017535, AA12870, AA11330
- substance use disorder;
- linkage disequilibrium
Abnormal serotonergic pathways are implicated in numerous neuropsychiatric disorders including alcohol and drug dependence (abuse). The human 5-hydroxytryptamine (serotonin) receptor 1B, encoded by the HTR1B (5-HT1B) gene, is a presynaptic serotonin autoreceptor that plays an important role in regulating serotonin synthesis and release. Although there was evidence of associations of the HTR1B gene variants in the etiologies of substance use disorders, negative findings were also reported. To clarify the roles of commonly reported single nucleotide polymorphisms (SNPs) of the HTR1B gene underlying alcohol and drug dependence (abuse), we performed a meta-analysis based on the available genotype data from individual candidate gene-based association studies. Evidence of association was found between the functional SNP −161A>T (rs130058) and alcohol, cocaine, and heroin dependence (e.g., P = 0.03 and odds ratio (OR) = 1.2 (1.02, 1.42) in the combined European, Asian, African, and Hispanic populations). SNP −261T>G (rs11568817) also showed evidence of association but with different directions in Europeans and non-Europeans (e.g., P = 0.0018 with OR = 1.42 (1.14, 1.76) and P = 0.01 with ORs = 0.5 (0.3, 0.85), respectively). This meta-analysis supports the associations of HTR1B −261T>G and −161A>T with alcohol and drug abuse and further investigations are warranted in larger samples. © 2013 Wiley Periodicals, Inc.