None of the authors report any conflict of interest.
Article first published online: 6 FEB 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 162, Issue 3, pages 227–234, April 2013
How to Cite
Jacobsen, K. K., Halmøy, A., Sánchez-Mora, C., Ramos-Quiroga, J. A., Cormand, B., Haavik, J. and Johansson, S. (2013), DISC1 in adult ADHD patients: An association study in two European samples. Am. J. Med. Genet., 162: 227–234. doi: 10.1002/ajmg.b.32136
How to Cite this Article: Jacobsen KK, Halmøy A, Sánchez-Mora C, Ramos-Quiroga JA, Cormand B, Haavik J, Johansson S. 2013. DISC1 in Adult ADHD Patients: An Association Study in Two European Samples. Am J Med Genet Part B 162B:227–234.
- Issue published online: 19 MAR 2013
- Article first published online: 6 FEB 2013
- Manuscript Accepted: 10 JAN 2013
- Manuscript Received: 30 NOV 2011
- Research Council of Norway
- Regional Health Authority of Western Norway
- K.G. Jebsen Foundation
- Instituto de Salud Carlos III. Grant Numbers: PI11/00571, PI11/01629
- Fundació La Marató de TV3. Grant Number: 092330/31
- Plan Nacional sobre Drogas. Grant Number: 2011/0080
- Ministerio de Economía y Competitividad, Spain. Grant Number: SAF2012-33484
- Agència de Gestió d'Ajuts Universitaris i de Recerca-. Grant Number: AGAUR 2009SGR0971
The DISC1 gene was named after its discovery in a Scottish pedigree with schizophrenia (SCZ) patients. However, subsequent studies have shown association of DISC1 variants with a range of different neurocognitive phenotypes and psychiatric disorders, including bipolar disorder (BPD), and major depression. Attention-deficit/hyperactivity disorder (ADHD) shares some symptoms with BPD and ADHD patients often suffer from comorbid affective disorders. We wanted to examine the role of DISC1 in ADHD, and with comorbid symptoms of mood disorders. Eleven single nucleotide polymorphisms (SNPs) previously implicated in SCZ and BPD, and a DISC1 duplication involving exon 1, were genotyped in 561 adult ADHD cases and 713 controls of Norwegian ancestry. The intronic SNP rs1538979 was associated with ADHD in the Norwegian sample [odds ratio (OR): 1.33, 95% confidence interval (CI) 1.03–1.73, P = 0.03] and replicated in a Spanish adult ADHD sample of 694 cases and 735 controls, using the tagging SNP rs11122330 (meta-analysis: P = 0.008, OR 1.25, 95% CI 1.06–1.47). In the Norwegian ADHD sample we also observed an association between the Phe607-variant of rs6675281 and a positive score on the Mood Disorder Questionnaire (MDQ; OR = 1.44, 95% CI 1.08–1.93, P = 0.01). To our knowledge, this is the first study to show an association between DISC1 variants and ADHD. Our study suggests that further studies are warranted to resolve if DISC1 variation is involved in several common neurodevelopmental disorders including ADHD. © 2013 Wiley Periodicals, Inc.