How to Cite this Article: Zhang Y, Wang Z-Z, Sun H-M. 2013. A Meta-Analysis of the Relationship of the Parkin p.Val380Leu Polymorphism to Parkinson's Disease. Am J Med Genet Part B 162B:235–244.
Article first published online: 21 FEB 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 162, Issue 3, pages 235–244, April 2013
How to Cite
Zhang, Y., Wang, Z.-Z. and Sun, H.-M. (2013), A meta-analysis of the relationship of the Parkin p.Val380Leu polymorphism to Parkinson's disease. Am. J. Med. Genet., 162: 235–244. doi: 10.1002/ajmg.b.32138
Conflict of interest: We confirm that there is no potential conflict of interest or financial dependence regarding this publication, as described in the Author Guidelines. We also confirm that all authors fulfill all conditions required for authorship. All authors have read and approved the manuscript.
- Issue published online: 19 MAR 2013
- Article first published online: 21 FEB 2013
- Manuscript Accepted: 17 JAN 2013
- Manuscript Received: 1 DEC 2011
- National Natural Science Foundation of China. Grant Numbers: 30873335, 81202507, 81202939
- Specialized Research Fund for the Doctoral Program of Higher Education of China. Grant Number: 20120013120007
- Autonomous Topics Fund of Beijing University of Chinese Medicine
- Parkinson's disease;
- p. Val380Leu polymorphism;
Parkinson's disease (PD) is one of the most common movement disorders. Parkin p.Val380Leu polymorphism (c.1239G > C) has been investigated as a potential genetic hallmark of PD, but studies examining the association between the polymorphism and PD have reported conflicting results. Therefore, we conducted a meta-analysis to assess the influence of Parkin p.Val380Leu polymorphism on the susceptibility of PD. Computer and hand searches of the literature were conducted using the MEDLINE, EMBASE, Cochrane Library, and China Academic Journals databases to identify studies addressing the association between the Parkin p.Val380Leu polymorphism and PD risk. We performed analyses of study characteristics, heterogeneity, and funnel plot asymmetry in analyses analogous to additive, dominant, recessive, homozygous, and heterozygous genetic models with the odds ratio (OR) as the measure of association. A total of 11 case–control studies involving 2,073 PD cases and 2,131 controls were included. When all 11 studies were pooled into the analysis, the presence of the Leu allele at the Parkin p.Val389Leu polymorphism was associated with decreased risk for PD in three genetic comparison models: OR in additive model: 0.79, 95% confidence interval (CI) = 0.64–0.98, P = 0.029; OR in recessive model: 0.55, 95% CI = 0.35–0.89, P = 0.014; OR in homozygous model: 0.51, 95% CI = 0.32–0.82, P = 0.005. Begg's funnel plot and Egger's test provided visual and statistical evidences for funnel plot symmetry, without evidence presence of publication bias. We conclude that the presence of the Leu allele at the Parkin p.Val380Leu polymorphism is associated decreased risk for PD. © 2013 Wiley Periodicals, Inc.