Collaborators of the Psychiatric GWAS Consortium: ADHD subgroup: Hans-Christoph Steinhausen (Aalborg, Denmark & Basel, and Zurich, Switzerland); Klaus-Peter Lesch, Andreas Reif, Tobias J. Renner, Marcel Romanos, Jasmin Romanos, SusanneWalitza, AndreasWarnke, ThuyTrang Nguyen, Helmut Schäfer (Würzburg and Marburg, Germany), Christine Freitag, Jobst Meyer, Haukur Palmason (Frankfurt/Homburg and Trier, Germany), Jan Buitelaar (Radboud University Nijmegen Medical Center, Donders Institute for Brain Cognition and Behavior, Nijmegen, Netherlands), Barbara Franke, Alejandro Arias Vasquez (Nijmegen/Utrecht, The Netherlands), Michael Gill, Richard J.L. Anney (Dublin, Ireland), Kate Langley, Michael O'Donovan, Nigel Williams, Peter Holmans, Michael Owen, Anita Thapar (Cardiff, Wales, UK), Lindsey Kent (St. Andrews, Scotland, UK), Joseph Sergeant (Amsterdam, The Netherlands), Herbert Roeyers (Gent, Belgium), Philip Asherson (London, UK), Eric Mick, Alysa Doyle, Joseph Biederman, (Boston, USA), Susan Smalley, Sandra Loo (Los Angeles, USA), Hakon Hakonarson, Josephine Elia (Philadelphia, USA), Alexandre Todorov (St. Louis, USA), Ana Miranda (Valencia, Spain), Richard Ebstein (Jerusalem, Israel), Aribert Rothenberger, Tobias Banaschewski (Mannheim/Goettingen, Germany), Robert Oades (Essen, Germany), James McGough (Los Angeles, USA), Frank Middleton (SUNY Upstate Medical University, Syracuse, NY), Xiaolan Hu (Pfizer, Groton, CT), Stan Nelson (UCLA, Los Angeles, CA), Benjamin M Neale (Boston, MA), Stephen V. Faraone (SUNY Upstate Medical University, Syracuse, NY, Chair). grant sponsor: German Research Association (DFG); grant numbers: He1446/9-1, KFO 125, SFB 581, GRK 1156, ME 1923/5-1, ME 1923/5-3, GRK 1389, SCHA 542/10-3; grant sponsor: Bundesministerium für Bildung und Forschung; grant number: BMBF 01GV0605; grant sponsor: US National of Institute of Health; Grant numbers: R13MH059126, R01MH62873, R01MH081803, K23MH066275, MH58277; grant sponsor: University of Pennsylvania CTR; grant number: UL1-RR-024134; grant sponsor: Institutional Development Award to the Center for Applied Genomics from the Children's Hospital of Philadelphia; grant sponsor: Affymetrix Power Award, 2007; grant sponsor: NHMRC (Australia); grant number: 443036; grant sponsor: Sidney Sax Public Health Fellowship; grant number: 443036; grant sponsor: Wellcome Trust, UK for sample; grant sponsor: UMC Utrecht Genvlag Grant; grant sponsor: Internal Grant of Radboud University Nijmegen Medical Centre.
Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder†
Article first published online: 26 MAR 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 162, Issue 4, pages 295–305, June 2013
How to Cite
Albayrak, Ö., Pütter, C., Volckmar, A.-L., Cichon, S., Hoffmann, P., Nöthen, M. M., Jöckel, K.-H., Schreiber, S., Wichmann, H.-E., Faraone, S. V., Neale, B. M., Herpertz-Dahlmann, B., Lehmkuhl, G., Sinzig, J., Renner, T. J., Romanos, M., Warnke, A., Lesch, K.-P., Reif, A., Schimmelmann, B. G., Scherag, A., Hebebrand, J., Hinney, A. and Psychiatric GWAS Consortium: ADHD Subgroup (2013), Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. Am. J. Med. Genet., 162: 295–305. doi: 10.1002/ajmg.b.32144
How to Cite this Article: Albayrak, Z, Pütter C, Volckmar A-L, Cichon S, Hoffmann P, Nöthen MM, Jöckel K-H, Schreiber S, Wichmann H-E, Faraone SV, Neale BM, Herpertz-Dahlmann B, Lehmkuhl G, Sinzig J, Renner TJ, Romanos M, Warnke A, Lesch K-P, Reif A, Schimmelmann BG, Scherag A, Hebebrand J, Hinney A, Psychiatric GWAS Consortium: ADHD Subgroup. 2013. Common Obesity Risk Alleles in Childhood Attention-Deficit/Hyperactivity Disorder. Am J Med Genet Part B 162B:295–305.
- Issue published online: 25 MAY 2013
- Article first published online: 26 MAR 2013
- Manuscript Accepted: 7 FEB 2013
- Manuscript Received: 4 FEB 2013
- German Ministry for Education and Research (National Genome Research Net plus). Grant Numbers: 01GS0820, 01KU0903
- German Research Foundation. Grant Numbers: DFG HE 1446/9-1, KFO 125/1-1, SCHA 542/10-2, ME 1923/5-1, ME 1923/5-3
- European Community's Seventh Framework Programme (FP7/2007-2013). Grant Number: 245009
- US National of Institute of Health Grants. Grant Numbers: R13MH059126, R01MH62873, R01MH081803, K23MH066275
- Children's Hospital of Philadelphia. Grant Number: UL1-RR-024134
- NHMRC (Australia) and Sidney Sax Public Health Fellowship. Grant Number: 443036
- body mass index;
- genetic risk factor;
- genome wide association study;
- weight regulation
Children with attention-deficit/hyperactivity disorder (ADHD) have a higher rate of obesity than children without ADHD. Obesity risk alleles may overlap with those relevant for ADHD. We examined whether risk alleles for an increased body mass index (BMI) are associated with ADHD and related quantitative traits (inattention and hyperactivity/impulsivity). We screened 32 obesity risk alleles of single nucleotide polymorphisms (SNPs) in a genome-wide association study (GWAS) for ADHD based on 495 patients and 1,300 population-based controls and performed in silico analyses of the SNPs in an ADHD meta-analysis comprising 2,064 trios, 896 independent cases, and 2,455 controls. In the German sample rs206936 in the NUDT3 gene (nudix; nucleoside diphosphate linked moiety X-type motif 3) was associated with ADHD risk (OR: 1.39; P = 3.4 × 10−4; Pcorr = 0.01). In the meta-analysis data we found rs6497416 in the intronic region of the GPRC5B gene (G protein-coupled receptor, family C, group 5, member B; P = 7.2 × 10−4; Pcorr = 0.02) as a risk allele for ADHD. GPRC5B belongs to the metabotropic glutamate receptor family, which has been implicated in the etiology of ADHD. In the German sample rs206936 (NUDT3) and rs10938397 in the glucosamine-6-phosphate deaminase 2 gene (GNPDA2) were associated with inattention, whereas markers in the mitogen-activated protein kinase 5 gene (MAP2K5) and in the cell adhesion molecule 2 gene (CADM2) were associated with hyperactivity. In the meta-analysis data, MAP2K5 was associated with inattention, GPRC5B with hyperactivity/impulsivity and inattention and CADM2 with hyperactivity/impulsivity. Our results justify further research on the elucidation of the common genetic background of ADHD and obesity. © 2013 Wiley Periodicals, Inc.