Next-generation sequencing in schizophrenia and other neuropsychiatric disorders
Article first published online: 17 OCT 2013
© 2013 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Special Issue: Identifying the Origins of Mental Illness: A Festschrift in Honor of Ming T. Tsuang
Volume 162, Issue 7, pages 671–678, October 2013
How to Cite
2013. Next-Generation Sequencing in Schizophrenia and Other Neuropsychiatric Disorders. Am J Med Genet Part B. 162B:671–678., , .
- Issue published online: 17 OCT 2013
- Article first published online: 17 OCT 2013
- Manuscript Accepted: 13 MAR 2013
- Manuscript Received: 7 JAN 2013
- whole exome;
Schizophrenia is a debilitating lifelong illness that lacks a cure and poses a worldwide public health burden. The disease is characterized by a heterogeneous clinical and genetic presentation that complicates research efforts to identify causative genetic variations. This review examines the potential of current findings in schizophrenia and in other related neuropsychiatric disorders for application in next-generation technologies, particularly whole-exome sequencing (WES) and whole-genome sequencing (WGS). These approaches may lead to the discovery of underlying genetic factors for schizophrenia and may thereby identify and target novel therapeutic targets for this devastating disorder. © 2013 Wiley Periodicals, Inc.