• Open Access

Convergent functional genomics of psychiatric disorders


  • Alexander B. Niculescu

    Corresponding author
    1. Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana
    2. Indianapolis VA Medical Center, Indianapolis, Indiana
    • Correspondence to:

      Alexander B. Niculescu, III, M.D., Ph.D., Associate Professor of Psychiatry and Medical Neuroscience, Indiana University School of Medicine, Indianapolis, IN; Staff Psychiatrist, Indianapolis VA Medical Center, Indianapolis, IN; Director, INBRAIN and Laboratory of Neurophenomics, Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN 46202-4887.

      E-mail: anicules@iupui.edu, www.neurophenomics.info

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  • This article was published online on 31 May 2013. Subsequently, it was determined that the final version had not been published, and this was corrected on 19 June 2013.


Genetic and gene expression studies, in humans and animal models of psychiatric and other medical disorders, are becoming increasingly integrated. Particularly for genomics, the convergence and integration of data across species, experimental modalities and technical platforms is providing a fit-to-disease way of extracting reproducible and biologically important signal, in contrast to the fit-to-cohort effect and limited reproducibility of human genetic analyses alone. With the advent of whole-genome sequencing and the realization that a major portion of the non-coding genome may contain regulatory variants, Convergent Functional Genomics (CFG) approaches are going to be essential to identify disease-relevant signal from the tremendous polymorphic variation present in the general population. Such work in psychiatry can provide an example of how to address other genetically complex disorders, and in turn will benefit by incorporating concepts from other areas, such as cancer, cardiovascular diseases, and diabetes. © 2013 Wiley Periodicals, Inc.