Financial disclosures: Dr. Barnett is an employee of Cambridge Cognition, a company that makes cognitive testing software. Dr. Sklar has served as a consultant for Pfizer, Inc., and is on the Board of Directors of Catalytic. Dr. Sullivan has received unrestricted research support from Eli Lilly and Expression Analysis (SAB). Dr. Perlis has received consulting fees or served on scientific advisory boards for Genomind, Healthrageous, Pamlab, Proteus Biomedical, and RIDVentures. He has received research support from Proteus Biomedical. He receives royalties/patent fees from Concordant Rater Systems (now UBC/Medco). Drs. McGrath, Cornelis, Lee, Robinson, Huang, Smoller and Ms. Gerber report no biomedical financial interests or potential conflicts of interest.
Genetic predictors of risk and resilience in psychiatric disorders: A cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia
Article first published online: 13 SEP 2013
© 2013 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 162, Issue 8, pages 779–788, December 2013
How to Cite
2013. Genetic Predictors of Risk and Resilience in Psychiatric Disorders: A Cross-Disorder Genome-Wide Association Study of Functional Impairment in Major Depressive Disorder, Bipolar Disorder, and Schizophrenia. Am J Med Genet Part B 162B:779–788., , , , , , , , , , , .
- Issue published online: 4 NOV 2013
- Article first published online: 13 SEP 2013
- Manuscript Accepted: 9 JUL 2013
- Manuscript Received: 18 MAR 2013
- National Institute of Mental Health
Additional supporting information may be found in the online version of this article at the publisher's web-site.
|ajmgb32190-sm-0001-SupFig-S1.tiff||1321K||Figure SI. Q-Q plot for MCS (λ = 1.007).|
|ajmgb32190-sm-0001-SupFig-S2.tiff||1321K||Figure SII. Manhattan plot for MCS.|
|ajmgb32190-sm-0001-SupFig-S3.tiff||1321K||Figure SIII. Q-Q plot for PCS (λ = 0.995).|
|ajmgb32190-sm-0001-SupFig-S4.tiff||1321K||Figure SIV. Manhattan plot for PCS.|
|ajmgb32190-sm-0001-SupFig-S5.tiff||191K||Figure SV. Region plot of PCS results in the interferon alpha gene cluster on chromosome 9. The figure shows the strong LD among SNPs in this region.|
Table SI. Psychiatric Symptoms Severity Constructs and Items Across Samples
Table SII. Regressions of MCS on Psychiatric Symptom Severity, Age, and Gender
Table SIII. Regressions of PCS on Psychiatric Symptom Severity, Age, and Gender
Table SIV. Logistic Regression of Employment Status on MCS and PCS Standardized Residuals
Table SV. Annotated Association Results With P < 0.0001 for the MCS. Provided as a separate excel file
Table SVI. Annotated association results with p < 0.0001 for the PCS. Provided as a separate excel file
Table SVII. Results From Genotype Confirmation for the Top Imputed SNPs in ADAMTS16 With PCS
Table SVIII. Results From the PCS Pathway Analysis for 186 KEGG Pathways at the 75% and 95% Thresholds
Table SIX. Results From the MCS Pathway Analysis for 186 KEGG Pathways at the 75% and 95% Thresholds
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