Susanne Jungwirth, Karl-Heinz Tragl, Peter Fischer, Peter Riederer, and Edna Grünblatt designed the study and wrote the protocol. Susanne Jungwirth and Peter Fischer contributed substantially to acquisition of subjects and data. Claus-Jürgen Scholz, Susanne Jungwirth, Wichart Ildiko, Heike Weber, Jürgen Deckert, and Edna Grünblatt managed the literature searches and analyses. Claus-Jürgen Scholz undertook the statistical analysis. Claus-Jürgen Scholz, Peter Riederer, Jürgen Deckert, and Edna Grünblatt wrote the first draft of the manuscript. All the authors contributed to and have approved the final manuscript.
Investigation of association of serotonin transporter and monoamine oxidase-A genes with Alzheimer's disease and depression in the VITA study cohort: A 90-month longitudinal study
Article first published online: 17 JAN 2014
© 2014 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 165, Issue 2, pages 184–191, March 2014
How to Cite
2014. Investigation of association of serotonin transporter and monoamine oxidase-A genes with Alzheimer's disease and depression in the VITA study cohort: A 90-month longitudinal study. Am J Med Genet Part B. 165B:184–191., , , , , , , , , .
None of the authors has any actual or potential conflict of interest, including any financial, personal or other relationships with other people or organizations within three years of beginning the work submitted that could inappropriately influence, or be perceived to influence, this work.
- Issue published online: 6 FEB 2014
- Article first published online: 17 JAN 2014
- Manuscript Accepted: 20 DEC 2013
- Manuscript Received: 6 MAR 2013
- Ludwig Boltzmann Institute of Aging Research, Vienna, Austria
- Alzheimer Forschung Initiativ (AFI), Germany
- IZKF grant. Grant Number: Z-6
- serotonin transporter;
- Alzheimer's disease;
Alzheimer's disease (AD) and depression (DE) are common psychiatric disorders strongly intertwined with one another. Nevertheless, etiology and early diagnosis of the disorders are still elusive. Several genetic variations have been suggested to associate with AD and DE, particularly in genes involved in the serotonergic system such as the serotonin transporter (SERT/SLC6A4), responsible for the removal from the synaptic cleft, and the monoamine-oxidase-A (MAOA), responsible for the presynaptic degradation of serotonin. Here, we attempt to characterize this pleiotropic effect for the triallelic SERT gene-linked polymorphic region (5HTTLPR) and for the MAOA-uVNTR, in participants in the Vienna-Transdanube-Aging (VITA)-study. The VITA-study is a community-based longitudinal study following a birth cohort (75 years old at baseline examination, n = 606) from Vienna for a period of 90 months with a regular follow-up interval of 30 months. Our main finding, confirming previous reports, is that the 5HTTLPR S-allele is a risk allele for DE (OR = 1.55 CI 95% 1.03–2.32) and its carriers had a steeper increase in SGDS sum score. No association to AD was found. MAOA-uVNTR did not associate with either AD or DE. However, in AD MAOA-uVNTR S-allele carriers a steeper increase of HAMD and STAI1 sum scores (P < 0.05) was observed. Although the VITA-study cohort is rather small with low power to detect gene alterations, the uniqueness of this very thoroughly investigated and homogenous cohort strengthens the results through exceptional data collection. Still, reinvestigation in a larger cohort similar to this, as well as a meta-analysis, is important to confirm these results. © 2014 Wiley Periodicals, Inc.