SEARCH

SEARCH BY CITATION

REFERENCES

  • Adam D. 2013. Mental health: On the spectrum. Nature 496(7446):416418.
  • Almasy L. 2003. Quantitative risk factors as indices of alcoholism susceptibility. Ann Med 35(5):337343.
  • Almasy L, Blangero JC. 2001. Endophenotypes as quantitative risk factors for psychiatric disease: Rationale and study design. Am J Med Genet 105(1):4244.
  • Blangero J. 2004. Localization and identification of human quantitative trait loci: King harvest has surely come. Curr Opin Genet Dev 14(3):233240.
  • Blangero J, Williams JT, Almasy L. 2003. Novel family-based approaches to genetic risk in thrombosis. J Thromb Haemost 1(7):13911397.
  • Blangero J, Diego VP, Dyer TD, Almeida M, Peralta J, Kent JW, Williams JT, Almasy L, Göring HH. 2013. A kernel of truth: Statistical advances in polygenic variance component models for complex human pedigrees. Adv Genet 81:131.
  • Blokland G, McMahon K, Hoffman J, Zhu G, Meredith M, Martin N, Thompson P, de Zubicaray G, Wright M. 2008. Quantifying the heritability of task-related brain activation and performance during the N-back working memory task: A twin fMRI study. Biol Psychol 79(1):7079.
  • Borovecki F, Lovrecic L, Zhou J, Jeong H, Then F, Rosas HD, Hersch SM, Hogarth P, Bouzou B, Jensen RV, Krainc D. 2005. Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease. Proc Natl Acad Sci USA 102(31):1102311028.
  • Bramon E, McDonald C, Croft RJ, Landau S, Filbey F, Gruzelier JH, Sham PC, Frangou S, Murray RM. 2005. Is the P300 wave an endophenotype for schizophrenia? A meta-analysis and a family study. Neuroimage 27(4):960968.
  • Breen G, Webb BT, Butler AW, van den Oord EJ, Tozzi F, Craddock N, Gill M, Korszun A, Maier W, Middleton L, Mors O, Owen MJ, Cohen-Woods S, Perry J, Galwey NW, Upmanyu R, Craig I, Lewis CM, Ng M, Brewster S, Preisig M, Rietschel M, Jones L, Knight J, Rice J, Muglia P, Farmer AE, McGuffin P. 2011. A genome-wide significant linkage for severe depression on chromosome 3: the depression network study. Am J Psychiatry 168(8):840847.
  • Comuzzie A, Hixson J, Almasy L, Mitchell B, Mahaney M, Dyer T, Stern M, MacCluer J, Blangero J. 1997. A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2. Nat Genet 15(3):273276.
  • Crow JF, Kimura M. 1970. An introduction to population genetics theory. New York: Harper & Row. 591 p. xiv.
  • Cuthbert BN, Insel TR. 2010. Toward new approaches to psychotic disorders: The NIMH Research Domain Criteria project. Schizophr Bull 36(6):10611062.
  • Ertekin-Taner N. 2011. Gene expression endophenotypes: A novel approach for gene discovery in Alzheimer's disease. Mol Neurodegener 6:31.
  • Falconer DS, Mackay TFC. 1996. Introduction to quantitative genetics, (4th ed). Harlow, England; New York: Prentice Hall. 464 p. xv.
  • Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, MacIntyre DJ, MacLean AW, St CD, Robinson M, Van Beck M, Pereira AC, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Ferrier IN, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N; Wellcome Trust Case Control Consortium. 2008. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 40(9):10561058.
  • Gershon E, Goldin L. 1986. Clinical methods in psychiatric genetics. I. Robustness of genetic marker investigative strategies. Acta Psychiatrica Scandinavica 74:113118.
  • Glahn D, Blangero J. 2011. Why endophenotype development requires families. Chin Sci Bull 56:33823384.
  • Glahn D, Therman S, Manninen M, Huttunen M, Kaprio J, Lönnqvist J, Cannon T. 2003. Spatial working memory as an endophenotype for schizophrenia. Biol Psychiatry 53(7):624626.
  • Glahn D, Ragland J, Abramoff A, Barrett J, Laird A, Bearden C, Velligan D. 2005. Beyond hypofrontality: A quantitative meta-analysis of functional neuroimaging studies of working memory in schizophrenia. Hum Brain Mapp 25(1):6069.
  • Glahn D, Almasy L, Blangero J, Burk G, Estrada J, Peralta J, Meyenberg N, Castro M, Barrett J, Nicolini H, Raventós H, Escamilla M. 2007a. Adjudicating neurocognitive endophenotypes for schizophrenia. Am J Med Genet B Neuropsychiatr Genet 144B(2):242249.
  • Glahn D, Thompson P, Blangero J. 2007b. Neuroimaging endophenotypes: Strategies for finding genes influencing brain structure and function. Hum Brain Mapp 28(6):488501.
  • Glahn D, Almasy L, Barguil M, Hare E, Peralta J, Kent JJ, Dassori A, Contreras J, Pacheco A, Lanzagorta N, Nicolini H, Raventós H, Escamilla M. 2010. Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families. Arch Gen Psychiatry 67(2):168177.
  • Glahn DC, Curran JE, Winkler AM, Carless MA, Kent JW, Charlesworth JC, Johnson MP, Göring HH, Cole SA, Dyer TD, Moses EK, Olvera RL, Kochunov P, Duggirala R, Fox PT, Almasy L, Blangero J. 2012. High dimensional endophenotype ranking in the search for major depression risk genes. Biol Psychiatry 71(1):614.
  • Goldman-Rakic PS. 1995. Cellular basis of working memory. Neuron 14(3):477485.
  • Goring HH, Curran JE, Johnson MP, Dyer TD, Charlesworth J, Cole SA, Jowett JB, Abraham LJ, Rainwater DL, Comuzzie AG, Mahaney MC, Almasy L, Maccluer JW, Kissebah AH, Collier GR, Moses EK, Blangero J. 2007. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat Genet 39(10):12081216.
  • Gottesman II, Gould TD. 2003. The endophenotype concept in psychiatry: Etymology and strategic intentions. Am J Psychiatry 160:636645.
  • Gottesman II, Shields J. 1972. Schizophrenia and genetics: A twin study vantage point. New York: Academic Press.
  • Gould DT, Gottesman II. 2006. Psychiatric endophenotypes and the development of valid animal models. Genes Brain Behav 5(2):113119.
  • Greenwood T, Braff D, Light G, Cadenhead K, Calkins M, Dobie D, Freedman R, Green M, Gur R, Gur R, Mintz J, Nuechterlein K, Olincy A, Radant A, Seidman L, Siever L, Silverman J, Stone W, Swerdlow N, Tsuang D, Tsuang M, Turetsky B, Schork N. 2007. Initial heritability analyses of endophenotypic measures for schizophrenia: The consortium on the genetics of schizophrenia. Arch Gen Psychiatry 64(11):12421250.
  • Hasler G, Drevets WC, Manji HK, Charney DS. 2004. Discovering endophenotypes for major depression. Neuropsychopharmacology 29(10):17651781.
  • Hasler G, Drevets WC, Gould TD, Gottesman II, Manji HK. 2006. Toward constructing an endophenotype strategy for bipolar disorders. Biol Psychiatry 60(2):93105.
  • Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K, Sanislow C, Wang P. 2010. Research domain criteria (RDoC): Toward a new classification framework for research on mental disorders. Am J Psychiatry 167(7):748751.
  • John B, Lewis KR. 1966. Chromosome variability and geographic distribution in insects. Science 152(3723):711721.
  • Johnstone EC, Lawrie SM, Cosway R. 2002. What does the Edinburgh high-risk study tell us about schizophrenia? Am J Med Genet 114(8):906912.
  • Kammerer CM, Schneider JL, Cole SA, Hixson JE, Samollow PB, O'Connell JR, Perez R, Dyer TD, Almasy L, Blangero J, Bauer RL, Mitchell BD. 2003. Quantitative trait loci on chromosomes 2p, 4p, and 13q influence bone mineral density of the forearm and hip in Mexican Americans. J Bone Miner Res 18(12):22452252.
  • Kapur S, Phillips AG, Insel TR. 2012. Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it? Mol Psychiatry 17(12):11741179.
  • Kathiresan S, Willer C, Peloso G, Demissie S, Musunuru K, Schadt E, Kaplan L, Bennett D, Li Y, Tanaka T, Voight B, Bonnycastle L, Jackson A, Crawford G, Surti A, Guiducci C, Burtt N, Parish S, Clarke R, Zelenika D, Kubalanza K, Morken M, Scott L, Stringham H, Galan P, Swift A, Kuusisto J, Bergman R, Sundvall J, Laakso M, Ferrucci L, Scheet P, Sanna S, Uda M, Yang Q, Lunetta K, Dupuis J, de Bakker P, O'Donnell C, Chambers J, Kooner J, Hercberg S, Meneton P, Lakatta E, Scuteri A, Schlessinger D, Tuomilehto J, Collins F, Groop L, Altshuler D, Collins R, Lathrop G, Melander O, Salomaa V, Peltonen L, Orho-Melander M, Ordovas J, Boehnke M, Abecasis G, Mohlke K, Cupples L. 2009. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet 41(1):5665.
  • Kiel D, Demissie S, Dupuis J, Lunetta K, Murabito J, Karasik D. 2007. Genome-wide association with bone mass and geometry in the Framingham Heart Study. BMC Med Genet 8(Suppl 1):S14.
  • Knowles E, Ma C, de Almeida M, Je C, Dr M, Sprooten E, Dyer T, Göring H, Olvera R, Fox P, L A, Duggirala R, Kent J, Blangero J, Glahn DC. 2014. Genome-wide significant localization for working and spatial memory: Identifying genes for psychosis using models of cognition. Am J Med Genet B Neuropsychiatr Genet 165B(1):8495.
  • Leboyer M, Bellivier F, Nosten-Bertrand M, Jouvent R, Pauls D, Mallet J. 1998. Psychiatric genetics: Search for phenotypes. Trends Neurosci 21(3):102105.
  • Lee J, Park S. 2005. Working memory impairments in schizophrenia: A meta-analysis. J Abnorm Psychol 114(4):599611.
  • Lee SH, Decandia TR, Ripke S, Yang J, Sullivan PF, Goddard ME, Keller MC, Visscher PM, Wray NR, (PGC-SCZ) TSPG-WASC, (ISC) TISC, (MGS) TMGoSC. 2012. Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet 44(3):247250.
  • Lenox RH, Gould TD, Manji HK. 2002. Endophenotypes in bipolar disorder. Am J Med Genet 114(4):391406.
  • Lenzenweger MF. 2013. Thinking clearly about the endophenotype-intermediate phenotype-biomarker distinctions in developmental psychopathology research. Dev Psychopathol 25(4 Pt 2):13471357.
  • Liu J, Pei Y, Papasian CJ, Deng HW. 2009. Bivariate association analyses for the mixture of continuous and binary traits with the use of extended generalized estimating equations. Genet Epidemiol 33(3):217227.
  • MacDonald AW, Thermenos HW, Barch DM, Seidman LJ. 2009. Imaging genetic liability to schizophrenia: Systematic review of FMRI studies of patients' nonpsychotic relatives. Schizophr Bull 35(6):11421162.
  • McDonald C, Bullmore ET, Sham PC, Chitnis X, Wickham H, Bramon E, Murray RM. 2004. Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Arch Gen Psychiatry 61(10):974984.
  • Meyer-Lindenberg A, Weinberger DR. 2006. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci 7(10):818827.
  • Miller GA, Rockstroh B. 2013. Endophenotypes in psychopathology research: Where do we stand? Annu Rev Clin Psychol 9:177213.
  • Minzenberg M, Laird A, Thelen S, Carter C, Glahn D. 2009. Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Arch Gen Psychiatry 66(8):811822.
  • Mitchell BD, Cole SA, Bauer RL, Iturria SJ, Rodriguez EA, Blangero J, MacCluer JW, Hixson JE. 2000. Genes influencing variation in serum osteocalcin concentrations are linked to markers on chromosomes 16q and 20q. J Clin Endocrinol Metab 85(4):13621366.
  • Narr KL, van Erp TG, Cannon TD, Woods RP, Thompson PM, Jang S, Blanton R, Poutanen VP, Huttunen M, Lonnqvist J, Standerksjold-Nordenstam CG, Kaprio J, Mazziotta JC, Toga AW. 2002. A twin study of genetic contributions to hippocampal morphology in schizophrenia. Neurobiol Dis 11(1):8395.
  • O'Donovan M, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini J, Spencer C, Howie B, Leung H, Hartmann A, Möller H, Morris D, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn E, Schulze T, Williams N, Giegling I, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders A, Levinson D, Gejman P, Cichon S, Nöthen M, Gill M, Corvin A, Rujescu D, Kirov G, Owen M, Buccola N, Mowry B, Freedman R, Amin F, Black D, Silverman J, Byerley W, Cloninger C. 2008. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 40(9):10531055.
  • Park S, Holzman PS. 1992. Schizophrenics show spatial working memory deficits. Arch Gen Psychiatry 49(12):975982.
  • Park S, Holzman PS, Goldman-Rakic PS. 1995. Spatial working memory deficits in the relatives of schizophrenic patients. Arch Gen Psychiatry 52(10):821828.
  • Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, Fujihara K, Havrdova E, Hutchinson M, Kappos L, Lublin FD, Montalban X, O'Connor P, Sandberg-Wollheim M, Thompson AJ, Waubant E, Weinshenker B, Wolinsky JS. 2011. Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria. Ann Neurol 69(2):292302.
  • Purcell S, Wray N, Stone J, Visscher P, O'Donovan M, Sullivan P, Sklar P, Consortium IS. 2009. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460(7256):748752.
  • Radich JP, Mao M, Stepaniants S, Biery M, Castle J, Ward T, Schimmack G, Kobayashi S, Carleton M, Lampe J, Linsley PS. 2004. Individual-specific variation of gene expression in peripheral blood leukocytes. Genomics 83(6):980988.
  • Reichenberg A, Harvey PD. 2007. Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings. Psychol Bull 133(5):833858.
  • Ripke S, Wray NR, Lewis CM, Hamilton SP, Weissman MM, Breen G, Byrne EM, Blackwood DH, Boomsma DI, Cichon S, Heath AC, Holsboer F, Lucae S, Madden PA, Martin NG, McGuffin P, Muglia P, Noethen MM, Penninx BP, Pergadia ML, Potash JB, Rietschel M, Lin D, Müller-Myhsok B, Shi J, Steinberg S, Grabe HJ, Lichtenstein P, Magnusson P, Perlis RH, Preisig M, Smoller JW, Stefansson K, Uher R, Kutalik Z, Tansey KE, Teumer A, Viktorin A, Barnes MR, Bettecken T, Binder EB, Breuer R, Castro VM, Churchill SE, Coryell WH, Craddock N, Craig IW, Czamara D, De Geus EJ, Degenhardt F, Farmer AE, Fava M, Frank J, Gainer VS, Gallagher PJ, Gordon SD, Goryachev S, Gross M, Guipponi M, Henders AK, Herms S, Hickie IB, Hoefels S, Hoogendijk W, Hottenga JJ, Iosifescu DV, Ising M, Jones I, Jones L, Jung-Ying T, Knowles JA, Kohane IS, Kohli MA, Korszun A, Landen M, Lawson WB, Lewis G, Macintyre D, Maier W, Mattheisen M, McGrath PJ, McIntosh A, McLean A, Middeldorp CM, Middleton L, Montgomery GM, Murphy SN, Nauck M, Nolen WA, Nyholt DR, O'Donovan M, Oskarsson H, Pedersen N, Scheftner WA, Schulz A, Schulze TG, Shyn SI, Sigurdsson E, Slager SL, Smit JH, Stefansson H, Steffens M, Thorgeirsson T, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Völzke H, Weilburg JB, Willemsen G, Zitman FG, Neale B, Daly M, Levinson DF, Sullivan PF, Consortium MDDWGotPG. 2013. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry 18(4):497511.
  • Rockman MV, Wray GA. 2002. Abundant raw material for cis-regulatory evolution in humans. Mol Biol Evol 19(11):19912004.
  • Silventoinen K, Sammalisto S, Perola M, Boomsma DI, Cornes BK, Davis C, Dunkel L, De Lange M, Harris JR, Hjelmborg JV, Luciano M, Martin NG, Mortensen J, Nistico L, Pedersen NL, Skytthe A, Spector TD, Stazi MA, Willemsen G, Kaprio J. 2003. Heritability of adult body height: A comparative study of twin cohorts in eight countries. Twin Res 6(5):399408.
  • Sing CF, Stengård JH, Kardia SL. 2003. Genes, environment, and cardiovascular disease. Arterioscler Thromb Vasc Biol 23(7):11901196.
  • Sklar P, Ripke S, Scott LJ, Andreassen OA, Cichon S, Craddock N, Edenberg HJ, Nurnberger JI, Rietschel M, Blackwood D, Corvin A, Flickinger M, Guan W, Mattingsdal M, McQuillin A, Kwan P, Wienker TF, Daly M, Dudbridge F, Holmans PA, Lin D, Burmeister M, Greenwood TA, Hamshere ML, Muglia P, Smith EN, Zandi PP, Nievergelt CM, McKinney R, Shilling PD, Schork NJ, Bloss CS, Foroud T, Koller DL, Gershon ES, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon FJ, Schulze TG, Berrettini W, Lohoff FW, Potash JB, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Breuer R, Meier S, Strohmaier J, Witt SH, Tozzi F, Farmer A, McGuffin P, Strauss J, Xu W, Kennedy JL, Vincent JB, Matthews K, Day R, Ferreira MA, O'Dushlaine C, Perlis R, Raychaudhuri S, Ruderfer D, Hyoun PL, Smoller JW, Li J, Absher D, Thompson RC, Meng FG, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Watson SJ, Myers RM, Akil H, Boehnke M, Chambert K, Moran J, Scolnick E, Djurovic S, Melle I, Morken G, Gill M, Morris D, Quinn E, Mühleisen TW, Degenhardt FA, Mattheisen M, Schumacher J, Maier W, Steffens M, Propping P, Nöthen MM, Anjorin A, Bass N, Gurling H, Kandaswamy R, Lawrence J, McGhee K, McIntosh A, McLean AW, Muir WJ, Pickard BS, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Jones IR, Kirov G, Moskvina V, Nikolov I, O'Donovan MC, Owen MJ, Collier DA, Elkin A, Williamson R, Young AH, Ferrier IN, Stefansson K, Stefansson H, Thornorgeirsson T, Steinberg S, Gustafsson O, Bergen SE, Nimgaonkar V, Hultman C, Landén M, Lichtenstein P, Sullivan P, Schalling M, Osby U, Backlund L, Frisén L, Langstrom N, Jamain S, Leboyer M, Etain B, Bellivier F, Petursson H, Sigur Sson E, Müller-Mysok B, Lucae S, Schwarz M, Schofield PR, Martin N, Montgomery GW, Lathrop M, Oskarsson H, Bauer M, Wright A, Mitchell PB, Hautzinger M, Reif A, Kelsoe JR, Purcell SM, Group PGCBDW. 2011. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet 43(10):977983.
  • Slaats-Willemse D, Swaab-Barneveld H, de Sonneville L, van der Meulen E, Buitelaar J. 2003. Deficient response inhibition as a cognitive endophenotype of ADHD. J Am Acad Child Adolesc Psychiatry 42(10):12421248.
  • Snitz BE, Macdonald AW, Carter CS. 2006. Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: A meta-analytic review of putative endophenotypes. Schizophr Bull 32(1):179194.
  • So HC, Gui AH, Cherny SS, Sham PC. 2011. Evaluating the heritability explained by known susceptibility variants: A survey of ten complex diseases. Genet Epidemiol 35(5):310317.
  • Speed D, Hemani G, Johnson MR, Balding DJ. 2012. Improved heritability estimation from genome-wide SNPs. Am J Hum Genet 91(6):10111021.
  • Sprooten E, Sussmann JE, Clugston A, Peel A, McKirdy J, Moorhead TW, Anderson S, Shand AJ, Giles S, Bastin ME, Hall J, Johnstone EC, Lawrie SM, McIntosh AM. 2011. White matter integrity in individuals at high genetic risk of bipolar disorder. Biol Psychiatry 70(4):350356.
  • Sprooten E, Brumbaugh MS, Knowles EE, McKay DR, Lewis J, Barrett J, Landau S, Cyr L, Kochunov P, Winkler AM, Pearlson GD, Glahn DC. 2013. Reduced white matter integrity in sibling pairs discordant for bipolar disorder. Am J Psychiatry 170(11):13171325.
  • Turkheimer E, Haley A, Waldron M, D'Onofrio B, Gottesman II. 2003. Socioeconomic status modifies heritability of IQ in young children. Psychol Sci 14(6):623628.
    Direct Link:
  • van Haren NE, Rijsdijk F, Schnack HG, Picchioni MM, Toulopoulou T, Weisbrod M, Sauer H, van Erp TG, Cannon TD, Huttunen MO, Boomsma DI, Hulshoff Pol HE, Murray RM, Kahn RS. 2012. The genetic and environmental determinants of the association between brain abnormalities and schizophrenia: The schizophrenia twins and relatives consortium. Biol Psychiatry 71(10):915921.
  • Whitney AR, Diehn M, Popper SJ, Alizadeh AA, Boldrick JC, Relman DA, Brown PO. 2003. Individuality and variation in gene expression patterns in human blood. Proc Natl Acad Sci USA 100(4):18961901.
  • Willer C, Speliotes E, Loos R, Li S, Lindgren C, Heid I, Berndt S, Elliott A, Jackson A, Lamina C, Lettre G, Lim N, Lyon H, McCarroll S, Papadakis K, Qi L, Randall J, Roccasecca R, Sanna S, Scheet P, Weedon M, Wheeler E, Zhao J, Jacobs L, Prokopenko I, Soranzo N, Tanaka T, Timpson N, Almgren P, Bennett A, Bergman R, Bingham S, Bonnycastle L, Brown M, Burtt N, Chines P, Coin L, Collins F, Connell J, Cooper C, Smith G, Dennison E, Deodhar P, Elliott P, Erdos M, Estrada K, Evans D, Gianniny L, Gieger C, Gillson C, Guiducci C, Hackett R, Hadley D, Hall A, Havulinna A, Hebebrand J, Hofman A, Isomaa B, Jacobs K, Johnson T, Jousilahti P, Jovanovic Z, Khaw K, Kraft P, Kuokkanen M, Kuusisto J, Laitinen J, Lakatta E, Luan J, Luben R, Mangino M, McArdle W, Meitinger T, Mulas A, Munroe P, Narisu N, Ness A, Northstone K, O'Rahilly S, Purmann C, Rees M, Ridderstråle M, Ring S, Rivadeneira F, Ruokonen A, Sandhu M, Saramies J, Scott L, Scuteri A, Silander K, Sims M, Song K, Stephens J, Stevens S, Stringham H, Tung Y, Valle T, Van Duijn C, Vimaleswaran K, Vollenweider P, Waeber G, Wallace C, Watanabe R, Waterworth D, Watkins N, Witteman J, Zeggini E, Zhai G, Zillikens M, Altshuler D, Caulfield M, Chanock S, Farooqi I, Ferrucci L, Guralnik J, Hattersley A, Hu F, Jarvelin M, Laakso M, Mooser V, Ong K, Ouwehand W, Salomaa V, Samani N, Spector T, Tuomi T, Tuomilehto J, Uda M, Uitterlinden A, Wareham N, Deloukas P, Frayling T, Groop L, Hayes R, Hunter D, Mohlke K, Peltonen L, Schlessinger D, Strachan D, Wichmann H, McCarthy M, Boehnke M, Barroso I, Abecasis G, Hirschhorn J. 2009. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41(1):2534.
  • Williams J, Blangero J. 2004. Power of variance component linkage analysis-II. Discrete traits. Ann Hum Genet 68(Pt 6):620632.
  • Williams JT, Van Eerdewegh P, Almasy L, Blangero J. 1999. Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results. Am J Hum Genet 65:11341147.
  • Wray GA. 2007. The evolutionary significance of cis-regulatory mutations. Nat Rev Genet 8(3):206216.
  • Yang J, Manolio TA, Pasquale LR, Boerwinkle E, Caporaso N, Cunningham JM, de Andrade M, Feenstra B, Feingold E, Hayes MG, Hill WG, Landi MT, Alonso A, Lettre G, Lin P, Ling H, Lowe W, Mathias RA, Melbye M, Pugh E, Cornelis MC, Weir BS, Goddard ME, Visscher PM. 2011. Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet 43(6):519525.
  • Yuan M, Diao G. 2011. Joint association analysis of bivariate quantitative and qualitative traits. BMC Proc 5(Suppl 9):S74.
  • Zou F, Carrasquillo MM, Pankratz VS, Belbin O, Morgan K, Allen M, Wilcox SL, Ma L, Walker LP, Kouri N, Burgess JD, Younkin LH, Younkin SG, Younkin CS, Bisceglio GD, Crook JE, Dickson DW, Petersen RC, Graff-Radford N, Ertekin-Taner N. 2010. Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease. Neurology 74: (6):480486.