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Reelin gene variants and risk of autism spectrum disorders: An integrated meta-analysis

Authors

  • Zhenling Wang,

    1. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • Yuan Hong,

    1. Department of Clinical Laboratory, Hubei Maternal and Child Health Hospital, Wuhan, China
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  • Li Zou,

    1. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • Rong Zhong,

    1. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • Beibei Zhu,

    1. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • Na Shen,

    1. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • Wei Chen,

    1. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • Jiao Lou,

    1. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • Juntao Ke,

    1. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • Ti Zhang,

    1. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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  • Weipeng Wang,

    Corresponding author
    1. Department of Clinical Laboratory, Hubei Maternal and Child Health Hospital, Wuhan, China
    • Correspondence to: Xiaoping Miao, Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

      E-mail: miaoxp@mail.hust.edu.cn

      Correspondence to: W. Wang, Department of Clinical Laboratory, Hubei Maternal and Child Health Hospital, Wuhan 430030, China.

      E-mail: wwp427@163.com

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  • Xiaoping Miao

    Corresponding author
    1. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    • Correspondence to: Xiaoping Miao, Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

      E-mail: miaoxp@mail.hust.edu.cn

      Correspondence to: W. Wang, Department of Clinical Laboratory, Hubei Maternal and Child Health Hospital, Wuhan 430030, China.

      E-mail: wwp427@163.com

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  • Zhenling Wang and Yuan Hong contributed equally to this work.
  • The authors have declared no conflicts of interest.

Abstract

Autism spectrum disorder (ASD) is a severe neurological disorder with a high degree of heritability. Reelin gene (RELN), which plays a crucial role in the migration and positioning of neurons during brain development, has been strongly posed as a candidate gene for ASD. Genetic variants in RELN have been investigated as risk factors of ASD in numerous epidemiologic studies but with inconclusive results. To clearly discern the effects of RELN variants on ASD, the authors conducted a meta-analysis integrating case–control and transmission disequilibrium test (TDT) studies published through 2001 to 2013. Odds ratios (ORs) with 95% confidence intervals were used to estimate the associations between three RELN variants (rs736707, rs362691, and GGC repeat variant) and ASD. In overall meta-analysis, the summary ORs for rs736707, rs362691, and GGC repeat variant were 1.11 [95% confidence interval (CI): 0.80–1.54], 0.69 (95% CI: 0.56–0.86), and 1.09 (95% CI: 0.97–1.23), respectively. Besides, positive result was also obtained in subgroup of broadly-defined ASD for rs362691 (OR = 0.67, 95% CI: 0.52–0.86). Our meta-analysis revealed that the RELN rs362691, rather than rs736707 or GGC repeat variant, might contribute significantly to ASD risk. © 2014 Wiley Periodicals, Inc.

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