Conflict of interest: Dr. Philibert is supported by R01MH080789 and R21DA034457. He is the Chief Scientific Officer for Behavioral Diagnostics whose product focus is epigenetic markers for substance use and is both an owner and a royalty recipient of granted and pending patents for the use of DNA methylation to diagnose substance use.
The search for peripheral biomarkers for major depression: Benefiting from successes in the biology of smoking
Version of Record online: 4 MAR 2014
© 2014 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Volume 165, Issue 3, pages 230–234, April 2014
How to Cite
2014. The search for peripheral biomarkers for major depression: Benefiting from successes in the biology of smoking. Am J Med Genet Part B 165B:230–234., , .
- Issue online: 5 APR 2014
- Version of Record online: 4 MAR 2014
- Manuscript Accepted: 29 JAN 2014
- Manuscript Received: 17 SEP 2013
- Deutsche Forschungsgemeinschaft and the Zukunftskolleg at the University of Konstanz
- European commission (Competitiveness and Innovation Framework Programme, CIP)
- German Research Foundation (DFG)
- Federal Ministry of Education and Research (BMBF)
- Heidelberg Academy of Sciences (WIN Kolleg)
- substance use;
- major depression;
The search for robust, clinically useful markers for major depression (MD) has been relatively unproductive. This is unfortunate because MD is one of the largest socio-economic challenges for much of the world and the development of reliable biomarkers for MD could aid in the prevention or treatment of this common syndrome. In this editorial, we compare the approaches taken in the search for biomarkers for MD to that of the more successful searches for biomarkers for tobacco use, and identify several substantive barriers. We suggest that many of the existing clinical repositories used in these biomarkers searches for MD may be of limited value. We conclude that in the future greater attention should be given to the clinical definitions, characterization of confounding environmental factors and age of subjects included in studies. © 2014 Wiley Periodicals, Inc.