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Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: Modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States†‡§

  1. Suzanne M. Gilboa¶,*,
  2. Cheryl S. Broussard‖,
  3. Owen J. Devine††,
  4. Kara N. Duwe‡‡,
  5. Audrey L. Flak§§,
  6. Sheree L. Boulet¶¶,
  7. Cynthia A. Moore‖‖,
  8. Martha M. Werler†††,
  9. Margaret A. Honein‡‡‡

Article first published online: 15 JUL 2011

DOI: 10.1002/ajmg.c.30306

Issue

American Journal of Medical Genetics Part C: Seminars in Medical Genetics

American Journal of Medical Genetics Part C: Seminars in Medical Genetics

Special Issue: Emerging Issues in Teratology

Volume 157, Issue 3, pages 234–246, 15 August 2011

Additional Information

How to Cite

Gilboa, S. M., Broussard, C. S., Devine, O. J., Duwe, K. N., Flak, A. L., Boulet, S. L., Moore, C. A., Werler, M. M. and Honein, M. A. (2011), Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: Modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States. Am. J. Med. Genet., 157: 234–246. doi: 10.1002/ajmg.c.30306

Author Information

  1. Suzanne M. Gilboa, Ph.D., M.H.S., is an Epidemiologist in the Division of Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention (CDC). Her research focuses on understanding risk factors for birth defects, including diabetes and obesity, environmental and occupational hazards and exposures, and medication use.

  2. ‖

    Cheryl S. Broussard, Ph.D., is a Health Scientist in the Division of Birth Defects and Developmental Disabilities at CDC. She joined CDC in 2007 as an Epidemic Intelligence Service officer in the Birth Defects Branch, where she focused on studying usage patterns and health outcomes associated with medication use during pregnancy. She currently chairs medication workgroups for both the National Birth Defects Prevention Study and CDC's Birth Defects Branch.

  3. ††

    Owen J. Devine, Ph.D., is a Mathematical Statistician in the National Center on Birth Defects and Developmental Disabilities at CDC. His areas of research include the application of mathematical modeling techniques to public health challenges with an emphasis on the uncertainty associated with model-based estimates.

  4. ‡‡

    Kara N. Duwe, M.P.H., is an Epidemiologist in the Division of Birth Defects and Developmental Disabilities at CDC. Her research focuses on understanding risk factors for birth defects, including medication use, smoking, and environmental exposures. She also works on health communication activities to promote new study findings.

  5. §§

    Audrey L. Flak, M.P.H., is an Oak Ridge Institute for Science and Education fellow in the Division of Birth Defects and Developmental Disabilities at CDC. Her primary research interest is the relationship between environmental exposures and reproductive health outcomes.

  6. ¶¶

    Sheree L. Boulet, Dr.P.H., M.P.H., is an Epidemiologist in the Division of Blood Disorders at the National Center on Birth Defects and Developmental Disabilities at CDC. Her research interests include preconception health, fetal growth restriction, macrosomia, and the health impact of chronic conditions in pediatric populations.

  7. ‖‖

    Cynthia A. Moore, M.D., Ph.D., is the Associate Director of Science in the Division of Birth Defects and Developmental Disabilities at CDC. Dr. Moore is a pediatrician and clinical geneticist. Her areas of research are birth defects and genetic disease epidemiology and her activities have focused on mechanisms of morphogenesis, classification of birth defects and genetic syndromes, prevention strategies for exposure to teratogens, and genetic and environmental risk factors for birth defects.

  8. †††

    Martha M. Werler, Sc.D., is a Professor of Epidemiology at Boston University Slone Epidemiology Center. Her work includes epidemiologic studies on a wide variety of risk factors for birth defects, with particular focus on medication use during pregnancy. She also conducts follow-up studies of outcomes among children born with birth defects.

  9. ‡‡‡

    Margaret (Peggy) A. Honein, Ph.D., M.P.H., is an Epidemiologist and Chief of the Birth Defects Branch in the Division of Birth Defects and Developmental Disabilities at CDC. Her research interests include the role of smoking in birth defects, assessing the safety or risk of medication use during pregnancy, understanding longer term outcomes associated with major birth defects, and evaluating the effects of infections, such as influenza, during pregnancy.

*National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Mail Stop E-86, 1600 Clifton Road, Atlanta, GA 30333.

  1. †

    This article is a US Government work and, as such, is in the public domain in the United States of America.

  2. ‡

    Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.

  3. §

    How to cite this article: Gilboa SM, Broussard CS, Devine OJ, Duwe KN, Flak AL, Boulet SL, Moore CA, Werler MM, Honein MA. 2011. Influencing clinical practice regarding the use of antiepileptic medications during pregnancy: Modeling the potential impact on the prevalences of spina bifida and cleft palate in the United States. Am J Med Genet Part C Semin Med Genet 157:234–246.

  4. Suzanne M. Gilboa, Ph.D., M.H.S., is an Epidemiologist in the Division of Birth Defects and Developmental Disabilities at the Centers for Disease Control and Prevention (CDC). Her research focuses on understanding risk factors for birth defects, including diabetes and obesity, environmental and occupational hazards and exposures, and medication use.

  5. ‖

    Cheryl S. Broussard, Ph.D., is a Health Scientist in the Division of Birth Defects and Developmental Disabilities at CDC. She joined CDC in 2007 as an Epidemic Intelligence Service officer in the Birth Defects Branch, where she focused on studying usage patterns and health outcomes associated with medication use during pregnancy. She currently chairs medication workgroups for both the National Birth Defects Prevention Study and CDC's Birth Defects Branch.

  6. ††

    Owen J. Devine, Ph.D., is a Mathematical Statistician in the National Center on Birth Defects and Developmental Disabilities at CDC. His areas of research include the application of mathematical modeling techniques to public health challenges with an emphasis on the uncertainty associated with model-based estimates.

  7. ‡‡

    Kara N. Duwe, M.P.H., is an Epidemiologist in the Division of Birth Defects and Developmental Disabilities at CDC. Her research focuses on understanding risk factors for birth defects, including medication use, smoking, and environmental exposures. She also works on health communication activities to promote new study findings.

  8. §§

    Audrey L. Flak, M.P.H., is an Oak Ridge Institute for Science and Education fellow in the Division of Birth Defects and Developmental Disabilities at CDC. Her primary research interest is the relationship between environmental exposures and reproductive health outcomes.

  9. ¶¶

    Sheree L. Boulet, Dr.P.H., M.P.H., is an Epidemiologist in the Division of Blood Disorders at the National Center on Birth Defects and Developmental Disabilities at CDC. Her research interests include preconception health, fetal growth restriction, macrosomia, and the health impact of chronic conditions in pediatric populations.

  10. ‖‖

    Cynthia A. Moore, M.D., Ph.D., is the Associate Director of Science in the Division of Birth Defects and Developmental Disabilities at CDC. Dr. Moore is a pediatrician and clinical geneticist. Her areas of research are birth defects and genetic disease epidemiology and her activities have focused on mechanisms of morphogenesis, classification of birth defects and genetic syndromes, prevention strategies for exposure to teratogens, and genetic and environmental risk factors for birth defects.

  11. †††

    Martha M. Werler, Sc.D., is a Professor of Epidemiology at Boston University Slone Epidemiology Center. Her work includes epidemiologic studies on a wide variety of risk factors for birth defects, with particular focus on medication use during pregnancy. She also conducts follow-up studies of outcomes among children born with birth defects.

  12. ‡‡‡

    Margaret (Peggy) A. Honein, Ph.D., M.P.H., is an Epidemiologist and Chief of the Birth Defects Branch in the Division of Birth Defects and Developmental Disabilities at CDC. Her research interests include the role of smoking in birth defects, assessing the safety or risk of medication use during pregnancy, understanding longer term outcomes associated with major birth defects, and evaluating the effects of infections, such as influenza, during pregnancy.

Publication History

  1. Issue published online: 19 JUL 2011
  2. Article first published online: 15 JUL 2011

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