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Embryonic cardiac chamber maturation: Trabeculation, conduction, and cardiomyocyte proliferation

Authors

  • Leigh Ann Samsa,

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    • Leigh Ann Samsa is a graduate student at the University of North Carolina, Chapel Hill. She completed her B.S. degree in Biology at Duke University. Her graduate research is focused on understanding genetic and epigenetic regulation of cardiac development.
  • Betsy Yang,

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    • Besty Yang is an undergraduate student majoring in biology at the University of North Carolina, Chapel Hill.
  • Jiandong Liu

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    • Jiandong Liu is an assistant Professor at the University of North Carolina, Chapel Hill. He received his Ph.D. from the University of Michigan, Ann Arbor and he performed his postdoctoral training at University of California, San Francisco. His laboratory is using zebrafish as a model system to study cardiac development and function.

  • Conflict of interest: none.

Correspondence to: Jiandong Liu, 8312C MBRB, 111 Mason Farm Rd, Chapel Hill, NC 27599. E-mail: jiandong_liu@med.unc.edu

Abstract

Congenital heart diseases are some of the most common human birth defects. Though some congenital heart defects can be surgically corrected, treatment options for other congenital heart diseases are very limited. In many congenital heart diseases, genetic defects lead to impaired embryonic heart development or growth. One of the key development processes in cardiac development is chamber maturation, and alterations in this maturation process can manifest as a variety of congenital defects including non-compaction, systolic dysfunction, diastolic dysfunction, and arrhythmia. During development, to meet the increasing metabolic demands of the developing embryo, the myocardial wall undergoes extensive remodeling characterized by the formation of muscular luminal protrusions called cardiac trabeculae, increased cardiomyocyte mass, and development of the ventricular conduction system. Though the basic morphological and cytological changes involved in early heart development are clear, much remains unknown about the complex biomolecular mechanisms governing chamber maturation. In this review, we highlight evidence suggesting that a wide variety of basic signaling pathways and biomechanical forces are involved in cardiac wall maturation. © 2013 Wiley Periodicals, Inc.

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