K.N. Lazaridis M.D. is a Consultant Hepatologist and the Enterprise Director of the Mayo Individualized Medicine Clinic. His research work focuses on the genetics of cholestatic liver diseases.
Implementing individualized medicine into the medical practice
Version of Record online: 10 MAR 2014
© 2014 Wiley Periodicals, Inc.
American Journal of Medical Genetics Part C: Seminars in Medical Genetics
Special Issue: Implementation of Genomic Medicine
Volume 166, Issue 1, pages 15–23, March 2014
How to Cite
2014. Implementing individualized medicine into the medical practice. Am J Med Genet Part C Semin Med Genet 166C:15–23., , , , , , , , , , , , , , , , , , , , , , .
Disclosures: Dr. R. Fonseca has received a patent for the prognostication of multiple myeloma based on genetic categorization of the disease. He has received consulting fees from Medtronic, Otsuka, Celgene, Genzyme, BMS, Lilly, Onyx, Binding Site, Millennium and AMGEN. He also has sponsored research from Cylene and Onyx.
* Correspondence to: Gianrico Farrugia, M.D., Mayo Clinic, 200 First Street SW, Rochester, MN 55905. E-mail: email@example.com
- Issue online: 18 MAR 2014
- Version of Record online: 10 MAR 2014
- genomic medicine;
- whole exome sequencing;
- individualized medicine clinic;
- personalized medicine
There is increasing recognition that genomic medicine as part of individualized medicine has a defined role in patient care. Rapid advances in technology and decreasing cost combine to bring genomic medicine closer to the clinical practice. There is also growing evidence that genomic-based medicine can advance patient outcomes, tailor therapy and decrease side effects. However the challenges to integrate genomics into the workflow involved in patient care remain vast, stalling assimilation of genomic medicine into mainstream medical practice. In this review we describe the approach taken by one institution to further individualize medicine by offering, executing and interpreting whole exome sequencing on a clinical basis through an enterprise-wide, standalone individualized medicine clinic. We present our experience designing and executing such an individualized medicine clinic, sharing lessons learned and describing early implementation outcomes. © 2014 Wiley Periodicals, Inc.