Genomic medicine implementation: Learning by example


  • Marc S. Williams

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    • Dr. Williams has been director of Geisinger Health System's Genomic Medicine Institute, since 2012. He has led genomic medicine implementation projects at Geisinger and at his previous institution Intermountain Healthcare. He is a member of the National Human Genome Research Institute's Genomic Medicine Working Group steering committee.

  • Conflict of interest: none.
  • * Correspondence to: Marc S. Williams, M.D., Genomic Medicine Institute, Geisinger Health System, 100N Academy Drive, Mail Stop 26-20, Danville, PA 17822-2026. E-mail:


Genomic Medicine is beginning to emerge into clinical practice. The National Human Genome Research Institute's Genomic Medicine Working Group consists of organizations that have begun to implement some aspect of genomic medicine (e.g., family history, systematic implementation of Mendelian disease program, pharmacogenomics, whole exome/genome sequencing). This article concisely reviews the working group and provides a broader context for the articles in the special issue including an assessment of anticipated provider needs and ethical, legal, and social issues relevant to the implementation of genomic medicine. The challenges of implementation of innovation in clinical practice and the potential value of genomic medicine are discussed. © 2014 Wiley Periodicals, Inc.