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Palladium-Catalyzed Decarboxylative Suzuki and Heck Couplings of Azaindole-2-carboxylic Acids: Synthesis of 2-Aryl/Alkenyl-1-phenylsulfonyl-1 H-pyrrolo-[2,3 b]pyridines



A series of 2-aryl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridines 3 were obtained by a palladium-catalyzed decarboxylative Suzuki coupling of azaindole-2-carboxylic acid derivative 1. The synthesis of alkenyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridines 9 by a related Heck coupling is also described. Protodecarboxylation operates in the case of azaindole-3-carboxylic acids under the reaction conditions.