C[BOND]C Coupling Through Intramolecular Dual C[BOND]H Activation Directed by a Removable Carboxylate Group: A Method for the Synthesis of Fluorenones under Mild Reaction Conditions

Authors

  • Lu Liu,

    1. Department of Chemistry, College of Science, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072 (China), Fax: (+86) 22-27403475
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  • Fang Wang,

    1. Department of Chemistry, College of Science, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072 (China), Fax: (+86) 22-27403475
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  • Zhenghong Li,

    1. Department of Chemistry, College of Science, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072 (China), Fax: (+86) 22-27403475
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  • Prof. Dr. Jianhui Wang

    Corresponding author
    1. Department of Chemistry, College of Science, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072 (China), Fax: (+86) 22-27403475
    • Department of Chemistry, College of Science, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072 (China), Fax: (+86) 22-27403475===

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Abstract

A highly efficient method for the synthesis of fluorenones through a palladium-catalyzed intramolecular oxidative coupling reaction via dual C[BOND]H activations is reported. In this reaction, substituted fluorenones were obtained in moderate to high yields from diphenylacetic acid and its derivatives as substrates. The carboxylate, as a removable directing group, plays an important role in the dual C[BOND]H activations of the substrate. The current method provides an efficient synthetic route for producing a variety of substituted fluorenones under mild reaction conditions.

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