Genetics and caging type affect birth weight in captive pigtailed macaques (Macaca nemestrina)
Article first published online: 7 MAR 2002
Copyright © 2002 Wiley-Liss, Inc.
American Journal of Primatology
Volume 56, Issue 4, pages 207–213, April 2002
How to Cite
Ha, J. C., Ha, R. R., Almasy, L. and Dyke, B. (2002), Genetics and caging type affect birth weight in captive pigtailed macaques (Macaca nemestrina). Am. J. Primatol., 56: 207–213. doi: 10.1002/ajp.1075
- Issue published online: 7 MAR 2002
- Article first published online: 7 MAR 2002
- Manuscript Accepted: 24 JAN 2002
- Manuscript Received: 19 JUL 2000
- NIH. Grant Numbers: RR00166, HD02274, RR13986, RR09950, MH59490
- quantitative genetics;
- variance decomposition;
- mitochondrial inheritance
The heritability of birth weight was estimated in 3,562 captive pigtailed macaques using 30 years of breeding and pedigree records. Based on a pedigree of over 12,000 animals, quantitative genetic analyses were performed using statistical variance decomposition methods. The model included additive genetic effects, cytoplasmic genetic effects, birth environment, shared maternal environment, and unmeasured environmental effects. The results demonstrated a strong (h2 = 0.51) heritable component of birth weight overall, and included significant additive genetic heritability (h2 = 0.23), and cytoplasmic heritability (h2 = 0.09). In addition, a significant effect of birth location and cage type was identified, explaining an additional 6% of birth weight variance. The use of a nonhuman primate model for studying the effects of genes on birth weight eliminated many of the problems associated with confounding variables in human studies, and allowed for the quantification of a heritable component of birth weight. Am. J. Primatol. 56:207–213, 2002. © 2002 Wiley-Liss, Inc.