Contract grant sponsor: NIH AARA; Contract grant number: RR018144-07; Contract grant sponsor: NIH NCRR; Contract grant numbers: RR05090-20; RR025871-03.
Single-Nucleotide Polymorphisms Reveal Patterns of Allele Sharing Across the Species Boundary Between Rhesus (Macaca mulatta) and Cynomolgus (M. fascicularis) Macaques
Article first published online: 15 NOV 2012
© 2012 Wiley Periodicals, Inc.
American Journal of Primatology
Volume 75, Issue 2, pages 135–144, February 2013
How to Cite
SATKOSKI TRASK, J. A., GARNICA, W. T., SMITH, D. G., HOUGHTON, P., LERCHE, N. and KANTHASWAMY, S. (2013), Single-Nucleotide Polymorphisms Reveal Patterns of Allele Sharing Across the Species Boundary Between Rhesus (Macaca mulatta) and Cynomolgus (M. fascicularis) Macaques. Am. J. Primatol., 75: 135–144. doi: 10.1002/ajp.22091
- Issue published online: 18 DEC 2012
- Article first published online: 15 NOV 2012
- Manuscript Accepted: 30 SEP 2012
- Manuscript Revised: 20 SEP 2012
- Manuscript Received: 2 MAR 2012
- NIH AARA. Grant Number: RR018144-07;
- NIH NCRR. Grant Numbers: R05090-20, RR025871-03
- ancestral character states
Both phenotypic and genetic evidence for asymmetric hybridization between rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques has been observed in the region of Indochina where both species are sympatric. The large-scale sharing of major histocompatibility complex (MHC) class II alleles between the two species in this region supports the hypothesis that genes, and especially genes involved in immune response, are being transferred across the species boundary. This differential introgression has important implications for the incorporation of cynomolgus macaques of unknown geographic origin in biomedical research protocols. Our study found that for 2,808 single-nucleotide polymorphism (SNP) markers, the minor allele frequencies (MAF) and observed heterozygosity calculated from a sample of Vietnamese cynomolgus macaques was significantly different from those calculated from samples of both Chinese rhesus and Indonesian cynomolgus macaques. SNP alleles from Chinese rhesus macaques were overrepresented in a sample of Vietnamese cynomolgus macaques relative to their Indonesian conspecifics and located in genes functionally related to the primary immune system. These results suggest that Indochinese cynomolgus macaques represent a genetically and immunologically distinct entity from Indonesian cynomolgus macaques. Am. J. Primatol. 75:135-144, 2013. © 2012 Wiley Periodicals, Inc.