This work was supported by Italian National Research Council (CNR) and in part by grants GM 17173 and HD 06003 from the U.S. National Institutes of Health, and a grant to PGL, a WHO Collaborating Center for references in Processing Human Genetics Data while P.L.W. was at the Population Genetics Laboratory, University of Hawaii, Honolulu.
Red cell acid phosphatase: Another polymorphism correlated with malaria?†
Article first published online: 3 MAY 2005
Copyright © 1975 Wiley-Liss, Inc., A Wiley Company
American Journal of Physical Anthropology
Volume 43, Issue 2, pages 177–185, September 1975
How to Cite
Palmarino, R., Agostino, R., Gloria, F., Lucarelli, P., Businco, L., Antognoni, G., Maggioni, G., Workman, P. L. and Bottini, E. (1975), Red cell acid phosphatase: Another polymorphism correlated with malaria?. Am. J. Phys. Anthropol., 43: 177–185. doi: 10.1002/ajpa.1330430205
- Issue published online: 3 MAY 2005
- Article first published online: 3 MAY 2005
- Acid phosphatase;
The frequency of PC allele for acid phosphatase in fourteen Sardinian villages correlates positively with the altitude and negatively with past malarial morbidity and GdMed prevalence.
The susceptibility towards hemolytic favism in Sardinian males with G6PD deficiency is dependent on the erythrocyte acid phosphatase and thalassemia phenotypes. Thalassemia trait exerts a protective action only in subjects carrying PA allele for acid phosphatase.
The data suggest that the gradient for malaria morbidity directly or indirectly, through interactions with thalassemia and G6PD polymorphisms, mediated by the habit of eating Vecia faba, may have had a significant role in determining the heterogeneous distribution of acid phosphatase polymorphism in Sardinia. Besides malaria, other environmental factors related with altitude seem to have been very important in shaping the present pattern of distribution of both acid phosphatase and G6PD polymorphisms in Sardinia.