A linkage study of protein-coding loci in Macaca mulatta and Macaca fascicularis

Authors

  • Robert E. Ferrell,

    1. Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences, University of Texas, Houston 77225
    Current affiliation:
    1. Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261
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  • Partha P. Majumder,

    1. Center for Demographic and Population Genetics, Graduate School of Biomedical Sciences, University of Texas, Houston 77225
    Current affiliation:
    1. Applied Statistics Division, Indian Statistical Institute, Calcutta, India
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  • David G. Smith

    1. Department of Anthropology, University of California, Davis, California 95616
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Abstract

Genealogical and gene marker data from the closely related species Macaca mulatta and Macaca fascicularis have been used to search for linkage between genes coding for the blood proteins albumin, carbonic anhydrase 1 and 2, diaphorase 1 and 2, group-specific component, glucose phosphate isomerase, hemoglobin alpha chains, isocitrate dehydrogenase, prealbumin, and transferrin. The results are consistent with conservation of the linkage between the loci coding for albumin and group-specific component and loci coding for the two carbonic anhydrase isozymes, as observed in other species. Among the 38 possible pairwise comparisons, no new linkage groups were identified. Tight linkage can be excluded for most pairs of loci.

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