mtDNA variation in Inuit populations of Greenland and Canada: Migration history and population structure
Article first published online: 13 DEC 2005
Copyright © 2005 Wiley-Liss, Inc.
American Journal of Physical Anthropology
Volume 130, Issue 1, pages 123–134, May 2006
How to Cite
Helgason, A., Pálsson, G., Pedersen, H. S., Angulalik, E., Gunnarsdóttir, E. D., Yngvadóttir, B. and Stefánsson, K. (2006), mtDNA variation in Inuit populations of Greenland and Canada: Migration history and population structure. Am. J. Phys. Anthropol., 130: 123–134. doi: 10.1002/ajpa.20313
- Issue published online: 5 APR 2006
- Article first published online: 13 DEC 2005
- Manuscript Accepted: 13 APR 2005
- Manuscript Received: 1 DEC 2004
- University of Iceland Research Fund
- Icelandic Greenland Fund
- population history;
- mitochondrial DNA;
We examined 395 mtDNA control-region sequences from Greenlandic Inuit and Canadian Kitikmeot Inuit with the aim of shedding light on the migration history that underlies the present geographic patterns of genetic variation at this locus in the Arctic. In line with previous studies, we found that Inuit populations carry only sequences belonging to haplotype clusters A2 and D3. However, a comparison of Arctic populations from Siberia, Canada, and Greenland revealed considerable differences in the frequencies of these haplotypes. Moreover, large sample sizes and regional information about birthplaces of maternal grandmothers permitted the detection of notable differences in the distribution of haplotypes among subpopulations within Greenland. Our results cast doubt on the prevailing hypothesis that contemporary Inuit trace their all of their ancestry to so-called Thule groups that expanded from Alaska about 800–1,000 years ago. In particular, discrepancies in mutational divergence between the Inuit populations and their putative source mtDNA pool in Siberia/Alaska for the two predominant haplotype clusters, A2a and A2b, are more consistent with the possibility that expanding Thule groups encountered and interbred with existing Dorset populations in Canada and Greenland. Am J Phys Anthropol, 2006. © 2005 Wiley-Liss, Inc.