Research Article

Argentine population genetic structure: Large variance in Amerindian contribution

  1. Michael F. Seldin1,*,
  2. Chao Tian1,
  3. Russell Shigeta1,
  4. Hugo R. Scherbarth2,
  5. Gabriel Silva3,
  6. John W. Belmont4,
  7. Rick Kittles5,
  8. Susana Gamron6,
  9. Alberto Allevi7,
  10. Simon A. Palatnik8,
  11. Alejandro Alvarellos9,
  12. Sergio Paira10,
  13. Cesar Caprarulo11,
  14. Carolina Guillerón12,
  15. Luis J. Catoggio13,
  16. Cristina Prigione14,
  17. Guillermo A. Berbotto15,
  18. Mercedes A. García16,
  19. Carlos E. Perandones17,
  20. Bernardo A. Pons-Estel18,
  21. Marta E. Alarcon-Riquelme19

Article first published online: 18 DEC 2006

DOI: 10.1002/ajpa.20534

Issue

American Journal of Physical Anthropology

American Journal of Physical Anthropology

Volume 132, Issue 3, pages 455–462, March 2007

Additional Information

How to Cite

Seldin, M. F., Tian, C., Shigeta, R., Scherbarth, H. R., Silva, G., Belmont, J. W., Kittles, R., Gamron, S., Allevi, A., Palatnik, S. A., Alvarellos, A., Paira, S., Caprarulo, C., Guillerón, C., Catoggio, L. J., Prigione, C., Berbotto, G. A., García, M. A., Perandones, C. E., Pons-Estel, B. A. and Alarcon-Riquelme, M. E. (2007), Argentine population genetic structure: Large variance in Amerindian contribution. Am. J. Phys. Anthropol., 132: 455–462. doi: 10.1002/ajpa.20534

Author Information

  1. 1

    Rowe Program in Human Genetics, Departments of Biological Chemistry and Medicine, University of California Davis, Davis, CA

  2. 2

    Servicio de Reumatología, Hospital Interzonal General de Agudos “Dr. Oscar Alende”, Mar del Plata, Argentina

  3. 3

    Obras Sociales del Hermano Pedro, Antigua, Guatemala

  4. 4

    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX

  5. 5

    Comprehensive Cancer Center, Ohio State University, Colombus, OH

  6. 6

    Servicio de Reumatología de la UHMI 1, Hospital Nacional de Clínicas, Universidad Nacional de Córdoba,Córdoba, Argentina

  7. 7

    Hospital General de Agudos Dr. Juán A. Fernandez, Buenos Aires, Argentina

  8. 8

    Facultad de Ciencias Medicas, Universidad Nacional de Rosario y Hospital Provincial del Centenario, Rosario, Argentina

  9. 9

    Servicio de Reumatología, Hospital Privado, Centro Medico de Córdoba, Córdoba, Argentina

  10. 10

    Hospital José M. Cullen, Santa Fe, Argentina

  11. 11

    Hospital Felipe Heras, Concordia, Entre Ríos, Argentina

  12. 12

    Departamento de Inmunología, Instituto de Investigaciones Médicas “Alfredo Lanari”, Buenos Aires, Argentina

  13. 13

    Sección Reumatología, Servicio de Clínica Médica, Hospital Italiano de Buenos Aires y Fundación Dr. Pedro M. Catoggio para el Progreso de la Reumatología, Buenos Aires, Argentina

  14. 14

    Servicio de Reumatología, Hospital Provincial de Rosario, Rosario, Argentina

  15. 15

    Servicio de Reumatología Hospital Escuela Eva Perón. Granadero Baigorria, Rosario, Argentina

  16. 16

    Servicio de Reumatología, Hospital Interzonal General de Agudos General San Martín, La Plata, Argentina

  17. 17

    Centro de Educación Médica e Investigaciones Clínicas (CEMIC), Buenos Aires, Argentina

  18. 18

    Sanatorio Parque, Rosario, Argentina

  19. 19

    Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden

*Room 4453, Tupper Hall, Department of Biological Chemistry: Med, One Shields Avenue, University of California, Davis, California 95616

Publication History

  1. Issue published online: 26 JAN 2007
  2. Article first published online: 18 DEC 2006
  3. Manuscript Accepted: 25 OCT 2006
  4. Manuscript Received: 22 MAR 2006

Funded by

  • NIH. Grant Number: R01 DK071185
  • Torsten and Ragnar Söderbergs Stiftelse
  • Swedish Research Council
  • Marcus Borsgtröms Foundation
  • Swedish Rheumatism Association
  • Gustav V: 80-year Jubilee
  • Royal Swedish Academy of Sciences

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Keywords:

  • ancestry informative markers;
  • admixture;
  • population stratification

Abstract

Argentine population genetic structure was examined using a set of 78 ancestry informative markers (AIMs) to assess the contributions of European, Amerindian, and African ancestry in 94 individuals members of this population. Using the Bayesian clustering algorithm STRUCTURE, the mean European contribution was 78%, the Amerindian contribution was 19.4%, and the African contribution was 2.5%. Similar results were found using weighted least mean square method: European, 80.2%; Amerindian, 18.1%; and African, 1.7%. Consistent with previous studies the current results showed very few individuals (four of 94) with greater than 10% African admixture. Notably, when individual admixture was examined, the Amerindian and European admixture showed a very large variance and individual Amerindian contribution ranged from 1.5 to 84.5% in the 94 individual Argentine subjects. These results indicate that admixture must be considered when clinical epidemiology or case control genetic analyses are studied in this population. Moreover, the current study provides a set of informative SNPs that can be used to ascertain or control for this potentially hidden stratification. In addition, the large variance in admixture proportions in individual Argentine subjects shown by this study suggests that this population is appropriate for future admixture mapping studies. Am J Phys Anthropol, 2007. © 2006 Wiley-Liss, Inc.

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