Mobile DNA elements in primate and human evolution
Article first published online: 28 NOV 2007
Copyright © 2007 Wiley-Liss, Inc.
American Journal of Physical Anthropology
Supplement: Yearbook of Physical Anthropology
Volume 134, Issue Supplement 45, pages 2–19, 2007
How to Cite
Xing, J., Witherspoon, D. J., Ray, D. A., Batzer, M. A. and Jorde, L. B. (2007), Mobile DNA elements in primate and human evolution. Am. J. Phys. Anthropol., 134: 2–19. doi: 10.1002/ajpa.20722
- Issue published online: 28 NOV 2007
- Article first published online: 28 NOV 2007
- National Science Foundation. Grant Numbers: BCS-0218370, BCS-0218338, EPS-0346411
- National Institutes of Health. Grant Number: GM-59290
- Louisiana Board of Regents Millennium Trust Health Excellence Fund HEF. Grant Numbers: (2000-05)-05, (2000-05)-01, (2001-06)-02
- primate phylogeny;
- human population genetics;
Roughly 50% of the primate genome consists of mobile, repetitive DNA sequences such as Alu and LINE1 elements. The causes and evolutionary consequences of mobile element insertion, which have received considerable attention during the past decade, are reviewed in this article. Because of their unique mutational mechanisms, these elements are highly useful for answering phylogenetic questions. We demonstrate how they have been used to help resolve a number of questions in primate phylogeny, including the human–chimpanzee–gorilla trichotomy and New World primate phylogeny. Alu and LINE1 element insertion polymorphisms have also been analyzed in human populations to test hypotheses about human evolution and population affinities and to address forensic issues. Finally, these elements have had impacts on the genome itself. We review how they have influenced fundamental ongoing processes like nonhomologous recombination, genomic deletion, and X chromosome inactivation. Yrbk Phys Anthropol 50:2–19, 2007. © 2007 Wiley-Liss, Inc.