Brief communication: Allelic and haplotypic structure at the DRD2 locus among five North Indian caste populations

Authors

  • Kallur N. Saraswathy,

    Corresponding author
    1. Biochemical and Molecular Anthropology Laboratory, Department of Anthropology, University of Delhi (North Campus), Delhi 110007, India
    • Department of Anthropology, University of Delhi, Delhi 110007, India
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  • S. Yaiphaba Meitei,

    1. Biochemical and Molecular Anthropology Laboratory, Department of Anthropology, University of Delhi (North Campus), Delhi 110007, India
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  • Vipin Gupta,

    1. South Asia Network for Chronic Disease, New Delhi, India
    Current affiliation:
    1. Research Fellow (Genetic Epidemiology), South Asia Network for Chronic Disease (SANCD), LSHTM/PHFT Collaboration, C-1/52, First Floor, Safderjung Development Area, New Delhi 110016, India
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  • Benrithung Murry,

    1. Biochemical and Molecular Anthropology Laboratory, Department of Anthropology, University of Delhi (North Campus), Delhi 110007, India
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  • Mohinder P. Sachdeva,

    1. Biochemical and Molecular Anthropology Laboratory, Department of Anthropology, University of Delhi (North Campus), Delhi 110007, India
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  • Pradeep K. Ghosh

    1. Biochemical and Molecular Anthropology Laboratory, Department of Anthropology, University of Delhi (North Campus), Delhi 110007, India
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Abstract

The dopamine D2 receptor (DRD2) gene, with its known human-specific derived alleles that can facilitate haplotype reconstruction, presents an important locus for anthropological studies. The three sites (TaqIA, TaqIB, and TaqID) of the DRD2 gene are widely studied in various world populations. However, no work has been previously published on DRD2 gene polymorphisms among North Indian populations. Thus, the present study attempts to understand the genetic structure of North Indian upper caste populations using the allele and haplotype frequencies and distribution patterns of the three TaqI sites of the DRD2 gene. Two hundred forty-six blood samples were collected from five upper caste populations of Himachal Pradesh (Brahmin, Rajput and Jat) and Delhi (Aggarwal and Sindhi), and analysis was performed using standard protocols. All three sites were found to be polymorphic in all five of the studied populations. Uniform allele frequency distribution patterns, low heterozygosity values, the sharing of five common haplotypes, and the absence of two of the eight possible haplotypes observed in this study suggest a genetic proximity among the selected populations. The results also indicate a major genetic contribution from Eurasia to North Indian upper castes, apart from the common genetic unity of Indian populations. The study also demonstrates a greater genetic inflow among North Indian caste populations than is observed among South Indian caste and tribal populations. Am J Phys Anthropol, 2010. © 2010 Wiley-Liss, Inc.

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