Research Article

Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers

  1. Winston Rojas1,*,
  2. María Victoria Parra1,†,
  3. Omer Campo1,
  4. María Antonieta Caro1,
  5. Juan Guillermo Lopera1,
  6. William Arias1,
  7. Constanza Duque1,
  8. Andrés Naranjo1,
  9. Jharley García1,
  10. Candelaria Vergara1,2,
  11. Jaime Lopera1,
  12. Erick Hernandez1,
  13. Ana Valencia1,
  14. Yuri Caicedo1,
  15. Mauricio Cuartas1,
  16. Javier Gutiérrez1,
  17. Sergio López1,
  18. Andrés Ruiz-Linares3,
  19. Gabriel Bedoya1

Article first published online: 8 JUN 2010

DOI: 10.1002/ajpa.21270

Issue

American Journal of Physical Anthropology

American Journal of Physical Anthropology

Volume 143, Issue 1, pages 13–20, September 2010

Additional Information

How to Cite

Rojas, W., Parra, M. V., Campo, O., Caro, M. A., Lopera, J. G., Arias, W., Duque, C., Naranjo, A., García, J., Vergara, C., Lopera, J., Hernandez, E., Valencia, A., Caicedo, Y., Cuartas, M., Gutiérrez, J., López, S., Ruiz-Linares, A. and Bedoya, G. (2010), Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers. Am. J. Phys. Anthropol., 143: 13–20. doi: 10.1002/ajpa.21270

Author Information

  1. 1

    Laboratory of Molecular Genetics, Institute of Biology, University of Antioquia, Medellín, Colombia

  2. 2

    Institute for Immunological Research, University of Cartagena, Cartagena, Colombia

  3. 3

    Department of Genetics, Evolution and Environment, University College, London, UK

  1. †

    WR and MVP participated equally in this work.

*Laboratorio de Genética Molecular, Instituto de Biologia, Universidad de Antioquia, Medellín, Colombia

Publication History

  1. Issue published online: 16 AUG 2010
  2. Article first published online: 8 JUN 2010
  3. Manuscript Accepted: 10 DEC 2009
  4. Manuscript Received: 13 AUG 2009

Funded by

  • Colombian Institute for the Development of Science and Technology, COLCIENCIAS. Grant Number: 111540520279
  • Programa de Sostenibilidad CODI 2009–2010 Universidad de Antioquia

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Keywords:

  • Colombia;
  • mestizo;
  • genetic markers;
  • admixture

Abstract

Colombia is a country with great geographic heterogeneity and marked regional differences in pre-Columbian native population density and in the extent of past African and European immigration. As a result, Colombia has one of the most diverse populations in Latin America. Here we evaluated ancestry in over 1,700 individuals from 24 Colombian populations using biparental (autosomal and X-Chromosome), maternal (mtDNA), and paternal (Y-chromosome) markers. Autosomal ancestry varies markedly both within and between regions, confirming the great genetic diversity of the Colombian population. The X-chromosome, mtDNA, and Y-chromosome data indicate that there is a pattern across regions indicative of admixture involving predominantly Native American women and European and African men. Am J Phys Anthropol 143:13–20, 2010. © 2010 Wiley-Liss, Inc.

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