Brief communication: Y-chromosome haplogroup analysis indicates that Chinese Tuvans share distinctive affinity with Siberian Tuvans

Authors

  • Zheng Chen,

    1. Department of Medical Genetics, Zhongshan Medical College, Sun Yat-Sen University, Guangzhou 510080, China
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    • The first two authors contributed equally to this work.

  • Yongke Zhang,

    1. Department of Medical Genetics, Zhongshan Medical College, Sun Yat-Sen University, Guangzhou 510080, China
    Current affiliation:
    1. Department of Clinical Medicine and Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Shenzhen Hospital of Peking University, Shenzhen 518036, China
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    • The first two authors contributed equally to this work.

  • An Fan,

    1. Department of Medical Statistics and Epidemiology, School of Public Health, Guangdong Medical College, Dongguan 523808, China
    2. Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
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  • Yanan Zhang,

    1. Department of Infertility Sterility and Sexology, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China
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  • Yanping Wu,

    1. Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100094, China
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  • Qianjun Zhao,

    1. Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100094, China
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  • Yong Zhou,

    1. Department of Biology, Xinjiang Medical University, Urumqi 830054, China
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  • Canlin Zhou,

    1. Department of Biology, Xinjiang Medical University, Urumqi 830054, China
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  • M. Bawudong,

    1. Department of Biology, Xinjiang Medical University, Urumqi 830054, China
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  • Xinmin Mao,

    1. Department of Biology, Xinjiang Medical University, Urumqi 830054, China
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  • Yuehui Ma,

    1. Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100094, China
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  • Lingyun Yang,

    1. Department of Medical Genetics, Zhongshan Medical College, Sun Yat-Sen University, Guangzhou 510080, China
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  • Yuanling Ding,

    1. Department of Medical Statistics and Epidemiology, School of Public Health, Guangdong Medical College, Dongguan 523808, China
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  • Xueqin Wang,

    Corresponding author
    1. Department of Statistical Sciences, School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, China
    • Department of Statistical Sciences, School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, China
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  • Shaoqi Rao

    Corresponding author
    1. Department of Medical Statistics and Epidemiology, School of Public Health, Guangdong Medical College, Dongguan 523808, China
    2. Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
    3. Department of Statistical Sciences, School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, China
    • Department of Medical Statistics and Epidemiology, School of Public Health, Guangdong Medical College, Dongguan 523808, China
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Abstract

Tuvans are mainly distributed in Siberia (the Republic of Tuva), Mongolia, and China. The genetic origin of Chinese Tuvans remains controversial. The Tuvans in China were classified as Mongolians in the early 1950s by the National Ethnic Affairs Commission of China, but they defined themselves as a separate group. To resolve this dispute and determine their genetic relationships with the peoples in Central Asia, we randomly selected 150 male subjects from the Tuvans in the Altai region of Xinjiang Uygur Autonomous Region in China. Fourteen Y chromosomal markers were genotyped using the RFLP method or direct sequencing. These haplogroup data were combined with public data for 15 populations in South Siberia and Central Asia. Tuvans in both China and the Republic of Tuva had the highest frequencies of haplogroups K-M9 and Q-M242. Principal component analysis demonstrated that the Tuvans in China were of a distinct cluster, separated from their neighbors, the Mongolians and Kazakhs, which finding was consistent with the Analysis of Molecular Variances. Further population tree analysis revealed that Tuvans were on a far-separated cluster from their neighbors. Based on these results, we propose that the Tuvans (in both China and the Republic of Tuva) constitute a group distinct from Mongolians and from other Central Asia populations. However, the genetic results might be the consequence of some evolutionary forces like genetic drift and founder effect, and do not necessarily reflect their ultimate origin. Am J Phys Anthropol, 2011. © 2011 Wiley-Liss, Inc.

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