Karima Fadhlaoui-Zid and Laura Rodríguez-Botigué are the first authors and contributed equally to this work.
Mitochondrial DNA structure in North Africa reveals a genetic discontinuity in the Nile Valley
Version of Record online: 10 FEB 2011
Copyright © 2011 Wiley-Liss, Inc.
American Journal of Physical Anthropology
Volume 145, Issue 1, pages 107–117, May 2011
How to Cite
Fadhlaoui-Zid, K., Rodríguez-Botigué, L., Naoui, N., Benammar-Elgaaied, A., Calafell, F. and Comas, D. (2011), Mitochondrial DNA structure in North Africa reveals a genetic discontinuity in the Nile Valley. Am. J. Phys. Anthropol., 145: 107–117. doi: 10.1002/ajpa.21472
- Issue online: 11 APR 2011
- Version of Record online: 10 FEB 2011
- Manuscript Accepted: 16 NOV 2010
- Manuscript Received: 1 OCT 2010
- Dirección General de Investigación, Ministerio de Ciencia e Innovación, Spain; Grant number: CGL2010-14944/BOS;
- Programa de Cooperación Interuniversitaria e Investigación Científica (AECI), Ministerio de Asuntos Exteriores y Cooperación, Spain. Grant Number: A/5180/06, A/8394/07, B/018514/08;
- Direcció General de Recerca, Generalitat de Catalunya; Grant number: 2009SGR1101;
- Tunisian Ministry of Higher Education and Scientific Research
- uniparental marker;
- gene flow
Human population movements in North Africa have been mostly restricted to an east-west direction due to the geographical barriers imposed by the Sahara Desert and the Mediterranean Sea. Although these barriers have not completely impeded human migrations, genetic studies have shown that an east-west genetic gradient exists. However, the lack of genetic information of certain geographical areas and the focus of some studies in parts of the North African landscape have limited the global view of the genetic pool of North African populations. To provide a global view of the North African genetic landscape and population structure, we have analyzed ∼2,300 North African mitochondrial DNA lineages (including 269 new sequences from Libya, in the first mtDNA study of the general Libyan population). Our results show a clinal distribution of certain haplogroups, some of them more frequent in Western (H, HV0, L1b, L3b, U6) or Eastern populations (L0a, R0a, N1b, I, J) that might be the result of human migrations from the Middle East, sub-Saharan Africa, and Europe. Despite this clinal pattern, a genetic discontinuity is found in the Libyan/Egyptian border, suggesting a differential gene flow in the Nile River Valley. Finally, frequency of the post-LGM subclades H1 and H3 is predominant in Libya within the H sequences, highlighting the magnitude of the LGM expansion in North Africa. Am J Phys Anthropol, 2011. © 2011 Wiley-Liss, Inc.