All authors declare that there are no competing interests.
Association of the FTO rs9939609 polymorphism with obesity in Roma/Gypsy population†
Article first published online: 12 OCT 2011
Copyright © 2011 Wiley Periodicals, Inc.
American Journal of Physical Anthropology
Volume 147, Issue 1, pages 30–34, January 2012
How to Cite
Mačeková, S., Bernasovský, I., Gabriková, D., Bôžiková, A., Bernasovská, J., Boroňová, I., Behulová, R., Švíčková, P., Petrejčíková, E., Soták, M., Sovičová, A. and Čarnogurská, J. (2012), Association of the FTO rs9939609 polymorphism with obesity in Roma/Gypsy population. Am. J. Phys. Anthropol., 147: 30–34. doi: 10.1002/ajpa.21604
- Issue published online: 14 DEC 2011
- Article first published online: 12 OCT 2011
- Manuscript Accepted: 18 JUL 2011
- Manuscript Received: 24 JAN 2011
- Research & Development Operational Programme funded by the ERDF. Grant Number: ITMS 26220120041
The rs9939609 SNP located in the first intron of the fat mass and obesity associated gene (FTO) has been found to be associated with common obesity mainly in populations of European descent. The Roma/Gypsy population as an ethnic minority of Asian Indian origin is well known for its adverse health status with a high prevalence of obesity. The main aim of this study was to examine the contribution of the rs9939609 FTO polymorphism to the high prevalence of obesity in the Roma/Gypsy population. Following a number of anthropometric measurements, the FTO rs9939609 polymorphism was genotyped in 312 Roma/Gypsy individuals. We observed significant differences in body mass index (BMI), waist circumference, and waist-to-hip ratio between different genotypes (P = 0.003, P = 0.012, and P = 0.03, respectively). The waist circumference in the subjects with AA genotype was about 7.1 cm larger than in those with TT genotypes (P = 0.005). However, the strongest association of minor allele A of the rs9939609 FTO polymorphism was found with BMI (odds ratio, 1.55; 95% confidence interval, 1.129–2.128; P = 0.007), even after adjusting for age, sex, and smoking status. This study provides the first report of allele and genotype frequencies for the rs9939609 polymorphism and also the first evidence of the association of the FTO variant with obesity in the Roma/Gypsy population. Am J Phys Anthropol, 2012. © 2011 Wiley Periodicals, Inc.