These authors contributed equally to this work.
The population genetics of quechuas, the largest native south american group: Autosomal sequences, SNPs, and microsatellites evidence high level of diversity
Article first published online: 27 JAN 2012
Copyright © 2012 Wiley Periodicals, Inc.
American Journal of Physical Anthropology
Volume 147, Issue 3, pages 443–451, March 2012
How to Cite
Scliar, M. O., Soares-Souza, G. B., Chevitarese, J., Lemos, L., Magalhães, W. C.S., Fagundes, N. J., Bonatto, S. L., Yeager, M., Chanock, S. J. and Tarazona-Santos, E. (2012), The population genetics of quechuas, the largest native south american group: Autosomal sequences, SNPs, and microsatellites evidence high level of diversity. Am. J. Phys. Anthropol., 147: 443–451. doi: 10.1002/ajpa.22013
- Issue published online: 13 FEB 2012
- Article first published online: 27 JAN 2012
- Manuscript Accepted: 9 DEC 2011
- Manuscript Received: 11 OCT 2011
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brazil)
- Fundação de Amparo a Pesquisa de Minas Gerais (Brazil)
- Brazilian Ministry of Education (Agency for the Development of Graduate Education-CAPES)
- National Cancer Institute
- native American;
- autosomal noncoding sequence;
Elucidating the pattern of genetic diversity for non-European populations is necessary to make the benefits of human genetics research available to individuals from these groups. In the era of large human genomic initiatives, Native American populations have been neglected, in particular, the Quechua, the largest South Amerindian group settled along the Andes. We characterized the genetic diversity of a Quechua population in a global setting, using autosomal noncoding sequences (nine unlinked loci for a total of 16 kb), 351 unlinked SNPs and 678 microsatellites and tested predictions of the model of the evolution of Native Americans proposed by (Tarazona-Santos et al.: Am J Hum Genet 68 (2001) 1485–1496). European admixture is <5% and African ancestry is barely detectable in the studied population. The largest genetic distances were between African versus Quechua or Melanesian populations, which is concordant with the African origin of modern humans and the fact that South America was the last part of the world to be peopled. The diversity in the Quechua population is comparable with that of Eurasian populations, and the allele frequency spectrum based on resequencing data does not reflect a reduction in the proportion of rare alleles. Thus, the Quechua population is a large reservoir of common and rare genetic variants of South Amerindians. These results are consistent with and complement our evolutionary model of South Amerindians (Tarazona-Santos et al.: Am J Hum Genet 68 (2001) 1485–1496), proposed based on Y-chromosome data, which predicts high genomic diversity due to the high level of gene flow between Andean populations and their long-term effective population size. Am J Phys Anthropol 2012. © 2012 Wiley Periodicals, Inc.