Brief communication: Adrenal androgens and aging: Female chimpanzees (Pan troglodytes) compared with women
Version of Record online: 2 JUL 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Physical Anthropology
Volume 151, Issue 4, pages 643–648, August 2013
How to Cite
Blevins, J. K., Coxworth, J. E., Herndon, J. G. and Hawkes, K. (2013), Brief communication: Adrenal androgens and aging: Female chimpanzees (Pan troglodytes) compared with women. Am. J. Phys. Anthropol., 151: 643–648. doi: 10.1002/ajpa.22300
- Issue online: 18 JUL 2013
- Version of Record online: 2 JUL 2013
- Manuscript Accepted: 29 APR 2013
- Manuscript Received: 8 JAN 2013
- NSF. Grant Number: BCS—0717886
- NIH. Grant Numbers: P01AG026423, P51RR000165
Additional Supporting Information may be found in the online version of this article.
|ajpa22300-sup-0001-suppfig1.eps||21895K||Figure S1: Models of DHEAS decline with age in subsamples of our chimpanzee sample distinguished by hormonal contraception. Each line represents a logarithmic model of the form y=a+b*ln(x). The solid line is fitted to the 53 measurements we used in which the subject was not on hormone contraception.…The estimated “a” constant is 191.73 (95% Confidence Interval: 113.34, 273.67) and the coefficient “b” = -37.77 (−62.90, −13.71). The dashed line is fit to the 12 measurements we used in which the subject was hormonally contracepted; a = 148.21 (31.78, 270.25), b = -21.68 (−58.71, 13.66).|
|ajpa22300-sup-0001-suppfig2.eps||9201K||Figure S2: Models of DHEAS decline with age in three human datasets. Each line represents an exponential model of the form y=e^(a+bx) fit to a sub-sample of our human data set. The solid line is fit to data from . The estimated “a” coefficient is 6.11 (95% Confidence Interval: 5.95, 6.24) and “b” = -0.026 (−0.030, −0.023). The dashed line represents a model fit to data from ; a = 6.65 (6.23, 7.12), b = -0.042 (−0.059, −0.028). The dotted line corresponds to a model of data from ; a = 6.48 (6.23, 6.73), b = -0.030 (−0.036, −0.024).|
|ajpa22300-sup-0003-supptable1.xlsx||53K||Table 1: Parameter estimates, sample size, and estimated maximum DHEAS at the start of adulthood for models of DHEAS loss in human and chimpanzee females. In all three models, x corresponds to years of age. The second row is a model fitted to data from Ravaglia et al. (1998), Sulcova et al. (1997), and Davison et al. (2005) detailed in Table S2. The third row describes a model fitted to 11 age-class means reported by Orentreich and colleagues (1984), which serves as check on the generality of our individual-based human model. To estimate maximum DHEAS (i.e., expected DHEAS concentration at the start of adulthood) reported in the last column, we evaluated our chimpanzee model at 15 years and the human models at 20 years.|
|ajpa22300-sup-0004-supptable2.xlsx||75K||Table 2: Slope of declining human and chimpanzee DHEAS concentrations averaged over five-year age intervals. To calculate an age interval's mean slope, we evaluated the relevant model (see Table 1 for parameter estimates) at the first and last years of the interval. We then subtracted the DHEAS estimate for the older age from that of the younger age and divided the resultant sum by five. The far right column shows the ratio of chimpanzee slope to human slope in each five-year interval following peak concentration.|
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