Brief communication: Effect of nomadic subsistence practices on lactase persistence associated genetic variation in Kuwait
Article first published online: 30 JUL 2013
Copyright © 2013 Wiley Periodicals, Inc.
American Journal of Physical Anthropology
Volume 152, Issue 1, pages 140–144, September 2013
How to Cite
Hill, S. C., Mohammad, T. R. and Kivisild, T. (2013), Brief communication: Effect of nomadic subsistence practices on lactase persistence associated genetic variation in Kuwait. Am. J. Phys. Anthropol., 152: 140–144. doi: 10.1002/ajpa.22313
- Issue published online: 23 AUG 2013
- Article first published online: 30 JUL 2013
- Manuscript Accepted: 3 MAY 2013
- Manuscript Received: 26 SEP 2012
- Pembroke College, Cambridge (to Sarah Hill)
- lactose tolerance;
Lactase persistence (LP)—the ability to digest lactose in adulthood—is paradigmatic of Holocenic dietary change affecting the evolutionary trajectory of specific populations. Kuwait represents one location of high LP where the variation in associated genomic regions has not been examined. Here, we present new sequence data from a 427 bp amplicon 14 kb upstream of the LCT (lactase) gene for two Bedouin tribal populations, the Ajman and Mutran. We estimate the frequency of known LP associated alleles and discuss the impact of nomadic-pastoralism on the associated genetic variation. We observe high frequency (56% on average) of the −13,915*G allele in both tribes, which is consistent with the high prevalence of LP in Kuwait. Whilst LP associated alleles occur in Kuwait at a similar frequency to other regional populations, we suggest that the −13,915*G allele frequency among the Kuwaiti Bedouin may be higher than among non-Bedouin Kuwaitis, possibly due to greater historical reliance on milk consumption or genetic drift. Am J Phys Anthropol 152:140–144, 2013. © 2013 Wiley Periodicals, Inc.