Funding sources for the study: NIH/National Institute of Biomedical Imaging and Bioengineering grants R01EB009557 and R01EB009557-01S1, under subcontract to the University of North Carolina from the Medical College of Wisconsin.
Article first published online: 27 AUG 2012
Copyright © 2013 American Rhinologic Society-American Academy of Otolaryngic Allergy, LLC
International Forum of Allergy & Rhinology
Volume 3, Issue 1, pages 48–55, January 2013
How to Cite
Frank, D. O., Kimbell, J. S., Cannon, D. and Rhee, J. S. (2013), Computed intranasal spray penetration: comparisons before and after nasal surgery. International Forum of Allergy & Rhinology, 3: 48–55. doi: 10.1002/alr.21070
Potential conflict of interest: None provided.
- Issue published online: 10 JAN 2013
- Article first published online: 27 AUG 2012
- Manuscript Accepted: 12 JUN 2012
- Manuscript Revised: 29 MAY 2012
- Manuscript Received: 26 MAR 2012
- computational fluid dynamics;
- computer modeling for nasal airflow;
- allergic rhinitis;
- topical therapy for chronic rhinosinusitis;
Quantitative methods for comparing intranasal drug delivery efficiencies pre- and postoperatively have not been fully utilized. The objective of this study is to use computational fluid dynamics techniques to evaluate aqueous nasal spray penetration efficiencies before and after surgical correction of intranasal anatomic deformities.
Ten three-dimensional models of the nasal cavities were created from pre- and postoperative computed tomography scans in 5 subjects. Spray simulations were conducted using a particle size distribution ranging from 10 μm to 110 μm, a spray speed of 3 m/second, plume angle of 68 degrees, and with steady state, resting inspiratory airflow present. Two different nozzle positions were compared. Statistical analysis was conducted using Student t test for matched pairs.
On the obstructed side, posterior particle deposition after surgery increased by 118% and was statistically significant (p = 0.036), while anterior particle deposition decreased by 13% and was also statistically significant (p = 0.020). The fraction of particles that bypassed the airways either pre- or postoperatively was less than 5%. Posterior particle deposition differences between obstructed and contralateral sides of the airways were 113% and 30% for pre- and postsurgery, respectively. Results showed that nozzle positions can influence spray delivery.
Simulations predicted that surgical correction of nasal anatomic deformities can improve spray penetration to areas where medications can have greater effect. Particle deposition patterns between both sides of the airways are more evenly distributed after surgery. These findings suggest that correcting anatomic deformities may improve intranasal medication delivery. For enhanced particle penetration, patients with nasal deformities may explore different nozzle positions. © 2013 ARS–AAOA, LLC.