Funding sources for the study: American Academy of Otolaryngic Allergy Foundation.
Safety of intradermal skin tests for inhalants and foods: a prospective study
Article first published online: 8 OCT 2012
© 2013 ARS-AAOA, LLC
International Forum of Allergy & Rhinology
Volume 3, Issue 3, pages 171–176, March 2013
How to Cite
How to Cite this Article: Safety of intradermal skin tests for inhalants and foods: a prospective study. Int Forum Allergy Rhinol, 2013; 3:171–176., , ,
Potential conflict of interest: None provided.
Presented at the Annual Meeting of the American Academy of Otolaryngic Allergy Foundation, September 9, 2011, San Francisco, CA
- Issue published online: 12 MAR 2013
- Article first published online: 8 OCT 2012
- Manuscript Revised: 7 JUN 2012
- Manuscript Accepted: 3 JUN 2012
- Manuscript Received: 6 MAR 2012
- American Academy of Otolaryngic Allergy Foundation
- intradermal skin tests;
- skin test safety;
- non-IgE-mediated food allergy;
- food allergy;
- inhalant allergy;
- subcutaneous immunotherapy
Intradermal skin testing is a useful allergy diagnostic tool. Although considered safe when properly performed, systemic reactions have been reported. This is the first large, prospective study to record and evaluate all systemic reactions from intradermal skin testing (IDT) to inhalant or food antigens.
A 24-month prospective study by 40 physician practices, recording all IDT tests, including reactions, symptoms, severity, time after injection, and reaction treatments.
Eighty systemic reactions (22 major) occurred among 20,530 patients (878,583 wheals). Nine had epinephrine treatment, 4 were observed in an emergency department, and there were no hospitalizations or fatalities. The overall systemic reaction risk was 0.009%. The risk of having a major reaction was 0.003%, or 1 reaction per 933 patients.
Intradermal skin tests for inhalants or foods, when performed with appropriate precautions, have a safety profile comparable to skin prick tests.